Wnt signal transduction: More than one way to skin a (beta-)cat?

被引：16

作者：

Eaton, S

Cohen, S

机构：

来源：

TRENDS IN CELL BIOLOGY | 1996年 / 6卷 / 08期

关键词：

D O I：

10.1016/0962-8924(96)20026-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Genetic and biochemical studies have suggested that signal transduction by the Wnt pathway is very different to the familiar protein-kinase cascade of the Ras pathway. Among the more intriguing findings is that beta-catenin, a component of intercellular adhesive junctions, is a central component in the Wnt signalling pathway. Recent studies suggest ways in which beta-catenin might serve as a focal point for regulation of adhesion, gene expression and cell proliferation.

引用

收藏

页码：287 / 290

页数：4

相关论文

共 40 条

[1]

ABERLE H, 1994, J CELL SCI, V107, P3655

[2] EXPRESSION OF WNT-1 IN PC12 CELLS RESULTS IN MODULATION OF PLAKOGLOBIN AND E-CADHERIN AND INCREASED CELLULAR ADHESION [J].

BRADLEY, RS ;

COWIN, P ;

BROWN, AMC .

JOURNAL OF CELL BIOLOGY, 1993, 123 (06) :1857-1865

[3] EMBRYONIC AXIS INDUCTION BY THE ARMADILLO REPEAT DOMAIN OF BETA-CATENIN - EVIDENCE FOR INTRACELLULAR SIGNALING [J].

FUNAYAMA, N ;

FAGOTTO, F ;

MCCREA, P ;

GUMBINER, BM .

JOURNAL OF CELL BIOLOGY, 1995, 128 (05) :959-968

[4]

GONZALEZ MA, 1994, EUR J PHARM BIOPHARM, V40, P183

[5] SIGNAL-TRANSDUCTION BY BETA-CATENIN [J].

GUMBINER, BM .

CURRENT OPINION IN CELL BIOLOGY, 1995, 7 (05) :634-640

[6]

Harding C V, 1971, Int Rev Cytol, V31, P215

[7] GLYCOGEN-SYNTHASE KINASE-3 AND DORSOVENTRAL PATTERNING IN XENOPUS EMBRYOS [J].

HE, X ;

SAINTJEANNET, JP ;

WOODGETT, JR ;

VARMUS, HE ;

DAWID, IB .

NATURE, 1995, 374 (6523) :617-622

[8] OVEREXPRESSION OF CADHERINS AND UNDEREXPRESSION OF BETA-CATENIN INHIBIT DORSAL MESODERM INDUCTION IN EARLY XENOPUS EMBRYOS [J].

HEASMAN, J ;

CRAWFORD, A ;

GOLDSTONE, K ;

GARNERHAMRICK, P ;

GUMBINER, B ;

MCCREA, P ;

KINTNER, C ;

NORO, CY ;

WYLIE, C .

CELL, 1994, 79 (05) :791-803

[9] WNT-1 MODULATES CELL-CELL ADHESION IN MAMMALIAN-CELLS BY STABILIZING BETA-CATENIN BINDING TO THE CELL-ADHESION PROTEIN CADHERIN [J].

HINCK, L ;

NELSON, WJ ;

PAPKOFF, J .

JOURNAL OF CELL BIOLOGY, 1994, 124 (05) :729-741

[10] ELECTRON-MICROSCOPIC OBSERVATIONS ON THE MAINTENANCE OF THE TIGHT JUNCTION DURING CELL-DIVISION IN THE EPITHELIUM OF THE MOUSE SMALL-INTESTINE [J].

JINGUJI, Y ;

ISHIKAWA, H .

CELL STRUCTURE AND FUNCTION, 1992, 17 (01) :27-37

← 1 2 3 4 →