Expanding small RNA interference

被引：319

作者：

Tuschl, T ^{[1
]}

机构：

[1] Max Planck Inst Biophys Chem, Dept Cellular Biochem, D-37077 Gottingen, Germany

来源：

NATURE BIOTECHNOLOGY | 2002年 / 20卷 / 05期

关键词：

D O I：

10.1038/nbt0502-446

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Several reports describe vector systems capable of producing small interfering RNAs for downregulating gene expression in mammalian cells.

引用

页码：446 / 448

页数：4

共 11 条

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[6] U6 promoter-driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells
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[J]. NATURE BIOTECHNOLOGY, 2002, 20 (05) : 497 - 500
[7] An unusually compact external promoter for RNA polymerase III transcription of the human H1RNA gene
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[J]. NUCLEIC ACIDS RESEARCH, 2001, 29 (12) : 2502 - 2509
[8] PADDISON PJ, 2002, IN PRESS GENES DEV, V16
[9] Effective expression of small interfering RNA in human cells
Paul, CP
Good, PD
Winer, I
Engelke, DR
[J]. NATURE BIOTECHNOLOGY, 2002, 20 (05) : 505 - 508
[10] Transcription by RNA polymerases I and III
Paule, MR
White, RJ
[J]. NUCLEIC ACIDS RESEARCH, 2000, 28 (06) : 1283 - 1298

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