A novel conserved family of nitric oxide synthase?

被引:29
作者
Zemojtel, T
Penzkofer, T
Dandekar, T
Schultz, J
机构
[1] Univ Wurzburg, Dept Bioinformat, D-97074 Wurzburg, Germany
[2] Max Planck Inst Mol Genet, Dept Computat Mol Biol, D-14195 Berlin, Germany
关键词
D O I
10.1016/j.tibs.2004.03.005
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We describe a novel system for the production of nitric oxide (NO) that is conserved in all eukaryotes and many bacteria. The prediction of candidate functional sites as well as the link to GTPase-based signaling could build the basis for experimental characterization of this novel protein family.
引用
收藏
页码:224 / 226
页数:3
相关论文
共 15 条
[1]   Cloning, expression, and characterization of a nitric oxide synthase protein from Deinococcus radiodurans [J].
Adak, S ;
Bilwes, AM ;
Panda, K ;
Hosfield, D ;
Aulak, KS ;
McDonald, JF ;
Tainer, JA ;
Getzoff, ED ;
Crane, BR ;
Stuehr, DJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (01) :107-112
[2]   Nitric oxide synthases: structure, function and inhibition [J].
Alderton, WK ;
Cooper, CE ;
Knowles, RG .
BIOCHEMICAL JOURNAL, 2001, 357 (03) :593-615
[3]   Identification of nitric oxide synthase in Staphylococcus aureus [J].
Choi, WS ;
Chang, MS ;
Han, JW ;
Hong, SY ;
Lee, HW .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 237 (03) :554-558
[4]   JPred: a consensus secondary structure prediction server [J].
Cuff, JA ;
Clamp, ME ;
Siddiqui, AS ;
Finlay, M ;
Barton, GJ .
BIOINFORMATICS, 1998, 14 (10) :892-893
[5]  
De La Torre JC, 2002, ANN NY ACAD SCI, V977, P196
[6]   Regulation of nitric oxide-sensitive guanylyl cyclase [J].
Friebe, A ;
Koesling, D .
CIRCULATION RESEARCH, 2003, 93 (02) :96-105
[7]   CHROMA: consensus-based colouring of multiple alignments for publication [J].
Goodstadt, L ;
Ponting, CP .
BIOINFORMATICS, 2001, 17 (09) :845-846
[8]   Identification of a plant nitric oxide synthase gene involved in hormonal signaling [J].
Guo, FQ ;
Okamoto, M ;
Crawford, NM .
SCIENCE, 2003, 302 (5642) :100-103
[9]   GeneNest: automated generation and visualization of gene indices [J].
Haas, SA ;
Beissbarth, T ;
Rivals, E ;
Krause, A ;
Vingron, M .
TRENDS IN GENETICS, 2000, 16 (11) :521-523
[10]  
Huang S, 1997, J NEUROCHEM, V69, P2516