Improved preparation of an amino acid type poly(ethylene glycol) derivative

被引：3

作者：

Hojo, K

Susuki, Y

Sasaki, M

Maeda, M

Smith, TJ

Kawasaki, K

机构：

[1] Kobe Gakuin Univ, Fac Pharmaceut Sci, Nishi Ku, Kobe, Hyogo 6512180, Japan

[2] Kobe Gakuin Univ, High Technol Res Ctr, Nishi Ku, Kobe, Hyogo 6512180, Japan

[3] Univ Pacific, Thomas J Long Sch Pharm & Hlth Sci, Stockton, CA 95211 USA

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2002年 / 50卷 / 07期

关键词：

poly(ethylene glycol); hybrid; poly(ethylene glycol) hybrid; peptide hybrid; amino acid type poly(ethylene glycol);

D O I：

10.1248/cpb.50.1001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An amino acid type poly(ethylene glycol) is a useful tool for preparation of a bi- or multivalent poly(ethylene glycol) hybrid of bioactive peptides, but synthesis is problematic. The amino acid type poly(ethylene glycol) was prepared from poly(oxyethylene)diglycolic acid followed by introduction of a fluorenylmethyloxycarbonyl group. The resulting product could be purified easily by LH-20 column chromatography and HPLC.

引用

收藏

页码：1001 / 1003

页数：3

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