Abnormal cortical voice processing in autism

被引:312
作者
Gervais, H
Belin, P
Boddaert, N
Leboyer, M
Coez, A
Sfaello, I
Barthélémy, C
Brunelle, F
Samson, Y
Zilbovicius, M
机构
[1] CEA, Serv Hosp Frederic Joliot, ERM 0205,INSERM, DRM,DSV, F-91406 Orsay, France
[2] Univ Montreal, Ctr Rech Neuropsychol & Cognit, Montreal, PQ, Canada
[3] Univ Montreal, Ctr Rech, Inst Univ Geriatrie Montreal, Montreal, PQ, Canada
[4] AP HP, Serv Radiol Pediat, F-75015 Paris, France
[5] Hop Henri Mondor, Psychiat Serv, AP HP, F-94000 Creteil, France
[6] CHU Bretonneau, INSERM, Unite 619, F-37000 Tours, France
[7] Grp Hosp Pitie Salpetriere, Serv Urgences Cerevrovasc, AP HP, F-75013 Paris, France
关键词
D O I
10.1038/nn1291
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Impairments in social interaction are a key feature of autism and are associated with atypical social information processing. Here we report functional magnetic resonance imaging (fMRI) results showing that individuals with autism failed to activate superior temporal sulcus (STS) voice-selective regions in response to vocal sounds, whereas they showed a normal activation pattern in response to nonvocal sounds. These findings suggest abnormal cortical processing of socially relevant auditory information in autism.
引用
收藏
页码:801 / 802
页数:2
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