A new analogue of rocaglamide by an oxidative dihydrofuran synthesis

被引：37

作者：

Schoop, A ^{[1
]}

Greiving, H ^{[1
]}

Göhrt, A ^{[1
]}

机构：

[1] Bayer AG, Cent Res, D-51638 Leverkusen, Germany

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 12期

关键词：

D O I：

10.1016/S0040-4039(00)00021-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new analogue of rocaglamide 1 has been synthesised. The tricyclic core structure that is lacking the C-8b hydroxy group was generated in an oxidative addition of 1,3-cyclohexanedione to a cyclopentene moiety forming a tricyclic dihydrofuran system. Further transformation gave analogue 12 with the desired configuration. Although this C-8b deoxy derivative exhibits no insecticidal activity, it provides important information in understanding the structure-activity relationship. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：1913 / 1916

页数：4

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