The immune and inflammatory response to Orf virus

被引：56

作者：

Haig, DM ^{[1
]}

McInnes, C ^{[1
]}

Deane, D ^{[1
]}

Reid, H ^{[1
]}

Mercer, A ^{[1
]}

机构：

[1] UNIV OTAGO, VIRUS RES UNIT, DUNEDIN, NEW ZEALAND

来源：

COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES | 1997年 / 20卷 / 03期

关键词：

Orf virus; parapox virus; immune and inflammatory response; mammals; sheep; human;

D O I：

10.1016/S0147-9571(96)00045-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Orf virus is a zoonotic, epitheliotropic DNA parapox virus that principally infects sheep and goats. The fact that the virus can repeatedly reinfect sheep has provoked an interest in the underlying cellular, virological and molecular mechanisms for its apparent escape from the host protective immune response. The local immune and inflammatory response in skin and the cell phenotype and cytokine response in lymph analysed around a single lymph node are characteristic of an anti-viral response. An unusual feature is the dense accumulation of MHC Class II+ dendritic cells in the skin lesion. The function of these cells is not known. Orf virus virulence genes and activities have been identified that may interfere with the development of the host protective immune and inflammatory response. (C) 1997 Elsevier Science Ltd.

引用

页码：197 / 204

页数：8

共 33 条

[1] Soluble interferon-gamma receptors encoded by poxviruses [J].