Human estrogen receptor-α:: regulation by synthesis, modification and degradation

被引：124

作者：

Reid, G ^{[1
]}

Denger, S ^{[1
]}

Kos, M ^{[1
]}

Gannon, R ^{[1
]}

机构：

[1] European Mol Biol Lab, D-69117 Heidelberg, Germany

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2002年 / 59卷 / 05期

关键词：

estrogen receptor-alpha; regulation; splicing; isoform; tissue specificity; proteasome; post-translational modification; ubiquitination; phosphorylation; acetylation;

D O I：

10.1007/s00018-002-8470-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review aims to evaluate the impact that human estrogen receptor-alpha (ER-alpha) synthesis, modification and degradation has on estrogen-dependant physiological and pathological processes within the body. Estrogen signaling is transduced through estrogen receptors, which act as ligand-inducible transcription factors. The significance of different isoforms of ER-alpha that lack structural features of full-length ER-alpha are discussed. The influence of differential promoter usage on the amount and isoform of ER-alpha within individual cell types is also reviewed. Moreover, the potential role of phosphorylation, ubiquitination and acetylation in the function and dynamic turnover of ER-alpha is presented.

引用

收藏

页码：821 / 831

页数：11

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