MDR1 and multidrug resistance-associated protein (MRP) gene expression in epithelial ovarian tumors

被引：40

作者：

Kavallaris, M

Leary, JA

Barrett, JA

Friedlander, ML

机构：

[1] UNIV SYDNEY,DEPT OBSTET & GYNAECOL,SYDNEY,NSW 2006,AUSTRALIA

[2] UNIV SYDNEY,WESTMEAD HOSP,DEPT MED ONCOL,WESTMEAD,NSW 2145,AUSTRALIA

[3] PRINCE WALES HOSP,DEPT MED ONCOL,RANDWICK,NSW 2031,AUSTRALIA

来源：

CANCER LETTERS | 1996年 / 102卷 / 1-2期

关键词：

ovarian tumor; MDR1; MRP; P-GLYCOPROTEIN; CELL-LINE; CANCER; TRANSPORTER; CARCINOMAS;

D O I：

10.1016/0304-3835(96)04143-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Clinical drug resistance poses a major problem in the successful treatment of ovarian cancer. Two genes, MDR1 and MRP, have been found to play a role in the multidrug resistance phenotype of a number of human tumors. Using a sensitive semiquantitative PCR assay we examined 53 primary untreated ovarian tumors for expression of both MDR1 and MRP genes. Approximately one-third of the tumors expressed MDR1 while all the tumors expressed varying levels of the MRP gene.

引用

页码：7 / 16

页数：10

共 35 条

[1]

BAILEY HH, 1994, P 7 SOC CLIN ONC 13, P135

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