Effects of statin therapy on vascular dysfunction

被引：26

作者：

Aikawa, M ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Excellence Vasc Biol Cardiovasc Med, Boston, MA 02115 USA

来源：

CORONARY ARTERY DISEASE | 2004年 / 15卷 / 05期

关键词：

atherosclerosis; vascular biology; acute coronary syndromes; inflammation; oxidative stress; macrophages; endothelial cells; statin; HMG-CoA reductase inhibitor; plaque stabilization;

D O I：

10.1097/01.mca.0000132583.04711.47

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Dyslipidemia and vascular inflammation play critical roles in the onset of acute coronary syndromes including myocardial infarction. Recent advances in cardiovascular medicine demonstrate that lipid-lowering therapy by 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) prevents acute coronary complications, probably by limiting inflammation in atheroma. Although a number of studies have suggested various effects of statins on vascular dysfunction independent of lipid lowering, the clinical benefits of such effects are not established as yet. (C) 2004 Lippincott Williams Wilkins.

引用

页码：227 / 233

页数：7

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