Say No to DMSO: Dimethylsulfoxide Inactivates Cisplatin, Carboplatin, and Other Platinum Complexes

被引：298

作者：

Hall, Matthew D. ^{[1
]}

Telma, Katherine A. ^{[1
]}

Chang, Ki-Eun ^{[1
]}

Lee, Tobie D. ^{[1
]}

Madigan, James P. ^{[1
]}

Lloyd, John R. ^{[2
]}

Goldlust, Ian S. ^{[3
]}

Hoeschele, James D. ^{[4
]}

Gottesman, Michael M. ^{[1
]}

机构：

[1] NCI, Cell Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

[2] NIDDK, Adv Mass Spectrometry Facil, NIH, Bethesda, MD USA

[3] NIH, Div Preclin Innovat, Chem Genom Ctr, Natl Ctr Adv Translat Sci, Rockville, MD USA

[4] Eastern Michigan Univ, Dept Chem, Ypsilanti, MI 48197 USA

来源：

CANCER RESEARCH | 2014年 / 74卷 / 14期

关键词：

DIMETHYL-SULFOXIDE; INFUSION SOLUTIONS; DEFENSE-MECHANISM; ANTICANCER DRUGS; BINDING-PROTEINS; CANCER-CELLS; DNA; RESISTANCE; ACCUMULATION; CHEMOTHERAPY;

D O I：

10.1158/0008-5472.CAN-14-0247

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The platinumdrugs cisplatin, carboplatin, and oxaliplatin are highly utilized in the clinic and as a consequence are extensively studied in the laboratory setting. In this study, we examined the literature and found a significant number of studies (11%-34%) in prominent cancer journals utilizing cisplatin dissolved in DMSO. However, dissolving cisplatin in DMSO for laboratory-based studies results in ligand displacement and changes to the structure of the complex. We examined the effect of DMSO on platinum complexes, including cisplatin, carboplatin, and oxaliplatin, finding that DMSO reacted with the complexes, inhibited their cytotoxicity and their ability to initiate cell death. These results render a substantial portion of the literature on cisplatin uninterpretable. Raising awareness of this significant issue in the cancer biology community is critical, and we make recommendations on appropriate solvation of platinum drugs for research. (C) 2014 AACR.

引用

页码：3913 / 3922

页数：10

共 51 条

[1]

The discovery and development of cisplatin [J].

Alderden, RA ;

Hall, MD ;

Hambley, TW .

JOURNAL OF CHEMICAL EDUCATION, 2006, 83 (05) :728-734

[2]

REACTIVITY OF SULFOXIDES TOWARD THE TETRACHLOROPLATINATE(II) ANION [J].

ANNIBALE, G ;

CATTALINI, L ;

CANOVESE, L ;

MICHELON, G ;

MARANGONI, G ;

TOBE, ML .

INORGANIC CHEMISTRY, 1983, 22 (06) :975-978

[3]

Towards Antitumor Active trans-Platinum Compounds [J].

Aris, Sheena M. ;

Farrell, Nicholas P. .

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2009, (10) :1293-1302

[4]

Oxaliplatin-induced gamma-H2AX activation via both p53-dependent and -independent pathways but is not associated with cell cycle arrest in human colorectal cancer cells [J].

Chiu, Shu-Jun ;

Lee, Yi-Jang ;

Hsu, Tzu-Sheng ;

Chen, Wen-Shu .

CHEMICO-BIOLOGICAL INTERACTIONS, 2009, 182 (2-3) :173-182

[5]

Satraplatin: an orally available platinum analog for the treatment of cancer [J].

Choy, Hak .

EXPERT REVIEW OF ANTICANCER THERAPY, 2006, 6 (07) :973-982

[6]

CHU G, 1994, J BIOL CHEM, V269, P787

[7]

Cruet-Hennequart S, 2009, CELL CYCLE, V8, P3039

[8]

Slowing of cisplatin aquation in the presence of DNA but not in the presence of phosphate: Improved understanding of sequence selectivity and the roles of monoaquated and diaquated species in the binding of cisplatin to DNA [J].

Davies, MS ;

Berners-Price, SJ ;

Hambley, TW .

INORGANIC CHEMISTRY, 2000, 39 (25) :5603-5613

[9]

Apparent interaction of dimethyl sulfoxide with cisplatin released from polymer delivery devices injected subcutaneously in dogs [J].

Dernell, WS ;

Straw, RC ;

Withrow, SJ ;

Powers, BE ;

Fujita, SM ;

Yewey, GS ;

Joseph, KF ;

Dunn, RL ;

Whitman, SL ;

Southard, GL .

JOURNAL OF DRUG TARGETING, 1998, 5 (05) :391-396

[10]

Stability of carboplatin and oxaliplatin in their infusion solutions is due to self-association [J].

Di Pasqua, Anthony J. ;

Kerwood, Deborah J. ;

Shi, Yi ;

Goodisman, Jerry ;

Dabrowiak, James C. .

DALTON TRANSACTIONS, 2011, 40 (18) :4821-4825

← 1 2 3 4 5 6 →