Structure and function of the T-cell receptor: Insights from x-ray crystallography

被引：42

作者：

Fields, BA

Mariuzza, RA

机构：

[1] Ctr. for Adv. Res. in Biotechnology, University of Maryland, Biotechnology Institute, Rockville, MD 20850

来源：

IMMUNOLOGY TODAY | 1996年 / 17卷 / 07期

关键词：

D O I：

10.1016/0167-5699(96)10020-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The long awaited information on the three-dimensional structure of the T-cell antigen receptor (TCR) has recently been reported. The structure of a TCR beta chain and that of a V alpha homodimer confirm predictions that TCR V and C domains closely resemble their immunoglobulin counterparts. However, as described here by Barry Fields and Roy Mariuzza, structural features have also been identified that are unique to the TCR and possibly important for peptide-MHC recognition and signal transduction.

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页码：330 / 336

页数：7

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