Long-term memory requires polyADP-ribosylation

被引：136

作者：

Cohen-Armon, M ^{[1
]}

Visochek, L

Katzoff, A

Levitan, D

Susswein, AJ

Klein, R

Valbrun, M

Schwartz, JH

机构：

[1] Tel Aviv Univ, Sackler Sch Med, Neufeld Cardiac Res Inst, Sheba Med Ctr, IL-69978 Tel Aviv, Israel

[2] Bar Ilan Univ, Fac Life Sci, Gonda Goldschmied Med Diagnost Res Ctr, IL-52900 Ramat Gan, Israel

[3] Columbia Univ, Ctr Neurobiol & Behav, New York, NY 10032 USA

来源：

SCIENCE | 2004年 / 304卷 / 5678期

关键词：

D O I：

10.1126/science.1096775

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

PolyADP-ribose-polymerase 1 is activated in neurons that mediate several forms of long-term memory in Aplysia. Because polyADP-ribosylation of nuclear proteins is a response to DNA damage in virtually all eukaryotic cells, it is surprising that activation of the polymerase occurs during learning and is required for long-term memory. We suggest that fast and transient decondensation of chromatin structure by polyADP-ribosylation enables the transcription needed to form long-term memory without strand breaks in DNA.

引用

页码：1820 / 1822

页数：3

共 33 条

[1] PARP-mediated proteasome activation: a co-ordination of DNA repair and protein degradation? [J].