The utilization of a unified pharmacophore query in the discovery of new antagonists of the adenosine receptor family

被引：27

作者：

Webb, TR

Melman, N

Lvovskiy, D

Ji, XD

Jacobson, KA

机构：

[1] ChemBridge Corp, San Diego, CA 92127 USA

[2] NIDDK, Mol Recognit Sect, Bioorgan Chem Lab, NIH, Bethesda, MD 20892 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(99)00583-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Pharmacophore queries from previously known potent selective A(3) antagonists were generated by Chem-X. These queries were used to search a pharmacophore database of diverse compounds (CNS-Set(TM)). In vitro assays of 186 'hits' yielded over 30 active compounds, for four adenosine receptor subtypes. This search strategy may also be applicable to the discovery of new ligands via receptor homology data. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：31 / 34

页数：4

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