Isolation and Biological Activities of Neomyrrhaol and Other Terpenes from the Resin of Commiphora myrrha

被引：64

作者：

Su, Shu-Lan ^{[1
,2
]}

Duan, Jin-Ao ^{[1
]}

Tang, Yu-Ping ^{[1
]}

Zhang, Xu ^{[1
]}

Yu, Li ^{[1
]}

Jiang, Feng-Rong ^{[1
]}

Zhou, Wei ^{[1
]}

Luo, Dan ^{[1
]}

Ding, An-Wei ^{[1
]}

机构：

[1] Nanjing Univ Chinese Med, Jiangsu Key Lab TCM Formulae Res, Nanjing 210046, Peoples R China

[2] Jiangsu Univ, Coll Pharm, Zhenjiang, Peoples R China

来源：

PLANTA MEDICA | 2009年 / 75卷 / 04期

关键词：

Commiphora myrrha; Burseraceae; resin; terpenes; aromatase inhibitory activity; effects on HUVEC growth; AROMATASE; TRITERPENOIDS; COMPONENTS;

D O I：

10.1055/s-0028-1112214

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

A new cycloartane-type triterpene named cycloartane-1 alpha,2 alpha,3 beta,25-tetraol (neomyrrhaol) (1), along with four known terpenes, sandaracopimaric acid (2), abietic acid (3), 2-methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one (4), and dehydroabietic acid (5) have been isolated from the resin of Commiphora myrrha. Their structures were elucidated by means of 1D, 2D NMR and HR-mass spectroscopy. Compounds 2 - 5 are known Compounds but not previously isolated from the resin of C. myrrha. Compounds 4 and 5 exhibited significant aromatase inhibiting activity with IC50 values at 0.2 mu M and 0.3 mu M, respectively. As shown in the MTT assay, 2, 3, 4, and 5 had inhibitory effects on HUVEC growth with IC50 values of 0.122 mu M (2), 0.125 mu M (3), 0.069 mu M (5). Compounds 1 - 5 did not inhibit contraction of the isolated uterine and did not protect HUVEC from damage induced by H2O2 at the tested concentration.

引用

页码：351 / 355

页数：5

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