Detection of hepatocellular carcinoma and its metastases with various pulse sequences using superparamagnetic iron oxide (SHU-555-A)

被引:19
作者
Arbab, AS [1 ]
Ichikawa, T [1 ]
Araki, T [1 ]
Toyama, K [1 ]
Nambu, A [1 ]
Ohsawa, S [1 ]
Kumagai, H [1 ]
Aikawa, Y [1 ]
机构
[1] Yamanashi Med Univ, Dept Radiol, Yamanashi 40938, Japan
来源
ABDOMINAL IMAGING | 2000年 / 25卷 / 02期
关键词
SPIO; SHU-555-A; HCC; metastasis; MRI; CTAP;
D O I
10.1007/s002619910035
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: To identify the most useful combinations of various pre- and postcontrast magnetic resonance (MR) image sequences in detecting hepatocellular carcinoma (HCC) and its intrahepatic metastases before and after injection of SHU-555-A. Methods: Thirty-eight lesions in 16 patients were evaluated before and after administration of SHU-555-A by using fast spin echo (FSE), gradient echo (GRE), and echo planar (EP) imaging sequences using a 1.5-Tesla superconducting MR system. The signal intensity ratio (SIR) and contrast-to-noise ratio (CNR) of the lesions, signal-to-noise ratios, and other parameters were calculated. Results: Tumors were better detected after injection of SHU-555-A on all pulse sequences except on out-of-phase T1-weighted (T1W)-GRE sequences. Tumor detectability was higher for precontrast EP imaging and T2*-weighted (T2*W)-GRE sequences, whereas detectability at postcontrast was higher for T2*W-GRE, proton-density weighted-FSE, and in-phase T1W-GRE sequences. The SIR and CNR at precontrast were highest for EP imaging, and those at postcontrast were highest for T2*W-GRE. Conclusion: SHU-555-A will increase the detectability of HCC and its liver metastases. T1W- and T2*W-GRE sequences would be the sequences of choice.
引用
收藏
页码:151 / 158
页数:8
相关论文
共 19 条
[1]   HEPATIC CIRRHOSIS AND HEPATITIS - MR IMAGING ENHANCED WITH SUPERPARAMAGNETIC IRON-OXIDE [J].
ELIZONDO, G ;
WEISSLEDER, R ;
STARK, DD ;
GUERRA, J ;
GARZA, J ;
FRETZ, CJ ;
TODD, LE ;
FERRUCCI, JT .
RADIOLOGY, 1990, 174 (03) :797-801
[2]   SUPERPARAMAGNETIC IRON OXIDE-ENHANCED MR IMAGING - PULSE SEQUENCE OPTIMIZATION FOR DETECTION OF LIVER-CANCER [J].
FRETZ, CJ ;
ELIZONDO, G ;
WEISSLEDER, R ;
HAHN, PF ;
STARK, DD ;
FERRUCCI, JT .
RADIOLOGY, 1989, 172 (02) :393-397
[3]   ENHANCEMENT OF LIVER HEMANGIOMAS ON T1-WEIGHTED MR SE IMAGES BY SUPERPARAMAGNETIC IRON-OXIDE PARTICLES [J].
GRANGIER, C ;
TOURNIAIRE, J ;
MENTHA, G ;
SCHIAU, R ;
HOWARTH, N ;
CHACHUAT, A ;
GROSSHOLZ, M ;
TERRIER, F .
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1994, 18 (06) :888-896
[4]   DETECTION OF LIVER METASTASES - COMPARISON OF SUPERPARAMAGNETIC IRON OXIDE-ENHANCED AND UNENHANCED MR-IMAGING ART 1.5 T WITH DYNAMIC CT, INTRAOPERATIVE US, AND PERCUTANEOUS US [J].
HAGSPIEL, KD ;
NEIDL, KFW ;
EICHENBERGER, AC ;
WEDER, W ;
MARINCEK, B .
RADIOLOGY, 1995, 196 (02) :471-478
[5]   SHU 555A - A NEW SUPERPARAMAGNETIC IRON-OXIDE CONTRAST AGENT FOR MAGNETIC-RESONANCE-IMAGING [J].
HAMM, B ;
STAKS, T ;
TAUPITZ, M .
INVESTIGATIVE RADIOLOGY, 1994, 29 :S87-S89
[6]   CONTRAST-ENHANCED MR-IMAGING OF LIVER AND SPLEEN - 1ST EXPERIENCE IN HUMANS WITH A NEW SUPERPARAMAGNETIC IRON-OXIDE [J].
HAMM, B ;
STAKS, T ;
TAPUITZ, M ;
MAIBAUER, R ;
SPEIDEL, A ;
HUPPERTZ, A ;
FRENZEL, T ;
LAWACZECK, R ;
WOLF, KJ ;
LANGE, L .
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING, 1994, 4 (05) :659-668
[7]  
HEIKIN JP, 1989, RADIOLOGY, V171, P467
[8]   Detection and characterization of hepatic tumors: Value of combined helical CT hepatic arteriography and CT during arterial portography [J].
Kanematsu, M ;
Hoshi, H ;
Imaeda, T ;
Murakami, T ;
Inaba, Y ;
Yokoyama, R ;
Nakamura, H .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1997, 168 (05) :1193-1198
[9]   HEPATIC-TUMORS - COMPARISON OF CT DURING ARTERIAL PORTOGRAPHY, DELAYED CT, AND MR IMAGING FOR PREOPERATIVE EVALUATION [J].
NELSON, RC ;
CHEZMAR, JL ;
SUGARBAKER, PH ;
BERNARDINO, ME .
RADIOLOGY, 1989, 172 (01) :27-34
[10]   DOES ADVANCED CIRRHOSIS WITH PORTOSYSTEMIC SHUNTING AFFECT THE VALUE OF CT ARTERIAL PORTOGRAPHY IN THE EVALUATION OF THE LIVER [J].
OLIVER, JH ;
BARON, RL ;
DODD, GD ;
PETERSON, MS ;
CARR, BI .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1995, 164 (02) :333-337