Controlled drug release for tissue engineering

被引：202

作者：

Rambhia, Kunal J. ^{[1
]}

Ma, Peter X. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Biol & Mat Sci, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Macromol Sci & Engn Ctr, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Dept Mat Sci & Engn, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF CONTROLLED RELEASE | 2015年 / 219卷

关键词：

Tissue engineering; Scaffold; Biomaterials; Regenerative medicine; Polymer; Controlled release; Drug delivery;

D O I：

10.1016/j.jconrel.2015.08.049

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Tissue engineering is often referred to as a three-pronged discipline, with each prong corresponding to 1) a 3D material matrix (scaffold), 2) drugs that act on molecular signaling, and 3) regenerative living cells. Herein we focus on reviewing advances in controlled release of drugs from tissue engineering platforms. This review addresses advances in hydrogels and porous scaffolds that are synthesized from natural materials and synthetic polymers for the purposes of controlled release in tissue engineering. We pay special attention to efforts to reduce the burst release effect and to provide sustained and long-term release. Finally, novel approaches to controlled release are described, including devices that allow for pulsatile and sequential delivery. In addition to recent advances, limitations of current approaches and areas of further research are discussed. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：119 / 128

页数：10

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