Long-term accumulation and microdistribution of uranium in the bone and marrow of beagle dog

被引：15

作者：

Arruda-Neto, JDT

Guevara, MVM

Nogueira, GP

Taricano, ID

Saiki, M

Zamboni, CB

Bonamin, LV

Camargo, SP

Cestari, AC

Deppman, A

Garcia, F

Gouveia, AN

Guzman, F

Helene, OAM

Jorge, SAC

Likhachev, VP

Martins, MN

Mesa, J

Rodriguez, O

Vanin, VR

机构：

[1] Univ Sao Paulo, Inst Phys, BR-05315970 Sao Paulo, Brazil

[2] Univ Santo Amaro, UNISA, UNITOX, Lab Toxicol Anal, Sao Paulo, Brazil

[3] High Inst Nucl Sci & Technol, Havana, Cuba

[4] UNESP, Fac Vet Med, Aracatuba, SP, Brazil

[5] IPEN, CNEN, Inst Energet & Nucl Res, Sao Paulo, Brazil

[6] Univ Sao Paulo, Inst Biol Sci, BR-05508 Sao Paulo, Brazil

[7] Butanta Inst, Lab Viral Inmunol, Sao Paulo, Brazil

[8] Santa Cruz State Univ, Ilheus, BA, Brazil

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 2004年 / 80卷 / 08期

基金：

巴西圣保罗研究基金会;

关键词：

D O I：

10.1080/09553000410001723884

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The accumulation and microdistribution of uranium in the bone and marrow of Beagle dogs were determined by both neutron activation and neutron-fission analysis. The experiment started immediately after the weaning period, lasting till maturity. Two animal groups were fed daily with uranyl nitrate at concentrations of 20 and 100 mug(-1) food. Of the two measuring techniques, uranium accumulated along the marrow as much as in the bone, contrary to the results obtained with single, acute doses. The role played by this finding for the evaluation of radiobiological long-term risks is discussed. It was demonstrated, by means of a biokinetical approach, that the long-term accumulation of uranium in bone and marrow could be described by a piling up of single dose daily incorporation.

引用

页码：567 / 575

页数：9

共 24 条

[1] Fat cells in red bone marrow of human rib: Their size and spatial distribution with respect to the radon-derived dose to the haemopoietic tissue [J].