No evidence of CRHR1 gene involvement in progressive supranuclear palsy

被引：2

作者：

Campdelacreu, Jaume ^{[1
]}

Gaig, Carles ^{[1
]}

Ezquerra, Mario ^{[1
]}

Munoz, Esteban ^{[1
]}

Marti, Maria Jose ^{[1
]}

Valldeoriola, Francesc ^{[1
]}

Tolosa, Eduardo ^{[1
]}

机构：

[1] Univ Barcelona, Hosp Clin Barcelona, Neurol Serv,Inst Clin Neurosci, Inst Invest Biomed August Pi I Sunyer,IDIBAPS,Par, E-08036 Barcelona, Spain

来源：

NEUROSCIENCE LETTERS | 2006年 / 409卷 / 01期

关键词：

progressive supranuclear palsy; genetics; haplotype; corticotropin releasing hormone receptor 1; gene; expression;

D O I：

10.1016/j.neulet.2006.09.017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Several genes have been located in the chromosomal region 17q21 genetically associated with progressive supranuclear palsy (PSP). Corticotropin releasing hormone receptor I (CRHR1) is a gene included in this region. In order to investigate the possible involvement of CRHR1 in PSP pathogenesis, we measured the globus pallidus mRNA expression of this gene using real-time PCR in 12 PSP comparing with several control groups composed by 10 Alzheimer's disease, 5 cerebrovascular disease and 6 healthy controls subjects. We furthermore sequenced directly the entire coding region of CRHR1 of two histopathologically confirmed PSP patients. Expression pattern of CRHR1 in globus pallidus was similar in all groups. We did not find any coding non-synonymous mutation in the patients analysed. Our results do not support an involvement of CRHR1 gene in PSP pathogenesis. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：61 / 64

页数：4

共 22 条

[1] The neuroprotective actions of corticotropin releasing hormone [J].

Bayatti, N ;

Behl, C .

AGEING RESEARCH REVIEWS, 2005, 4 (02) :258-270

[2] Brain region-specific neuroprotective action and signaling of corticotropin-releasing hormone in primary neurons [J].

Bayatti, N ;

Zschocke, J ;

Behl, C .

ENDOCRINOLOGY, 2003, 144 (09) :4051-4060

[3] Identification of a novel polymorphism in the promoter region of the tau gene highly associated to progressive supranuclear palsy in humans [J].

Ezquerra, M ;

Pastor, P ;

Valldeoriola, F ;

Molinuevo, JL ;

Blesa, R ;

Tolosa, E ;

Oliva, R .

NEUROSCIENCE LETTERS, 1999, 275 (03) :183-186

[4]

Ezquerra M, 2004, J NEUROL NEUROSUR PS, V75, P155

[5] Optimal asymptotic estimation of small exceedance probabilities [J].

Ferreira, A .

JOURNAL OF STATISTICAL PLANNING AND INFERENCE, 2002, 104 (01) :83-102

[6] Mutational analysis of the tau gene in progressive supranuclear palsy [J].

Higgins, JJ ;

Adler, RL ;

Loveless, JM .

NEUROLOGY, 1999, 53 (07) :1421-1424

[7] The tau gene A0 allele and progressive supranuclear palsy [J].

Hoenicka, J ;

Pérez, M ;

Pérez-Tur, J ;

Barabash, A ;

Godoy, M ;

Vidal, L ;

Astarloa, R ;

Avila, J ;

Nygaard, T ;

de Yébenes, JG .

NEUROLOGY, 1999, 53 (06) :1219-1225

[8] Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17 [J].

Hutton, M ;

Lendon, CL ;

Rizzu, P ;

Baker, M ;

Froelich, S ;

Houlden, H ;

Pickering-Brown, S ;

Chakraverty, S ;

Isaacs, A ;

Grover, A ;

Hackett, J ;

Adamson, J ;

Lincoln, S ;

Dickson, D ;

Davies, P ;

Petersen, RC ;

Stevens, M ;

de Graaff, E ;

Wauters, E ;

van Baren, J ;

Hillebrand, M ;

Joosse, M ;

Kwon, JM ;

Nowotny, P ;

Che, LK ;

Norton, J ;

Morris, JC ;

Reed, LA ;

Trojanowski, J ;

Basun, H ;

Lannfelt, L ;

Neystat, M ;

Fahn, S ;

Dark, F ;

Tannenberg, T ;

Dodd, PR ;

Hayward, N ;

Kwok, JBJ ;

Schofield, PR ;

Andreadis, A ;

Snowden, J ;

Craufurd, D ;

Neary, D ;

Owen, F ;

Oostra, BA ;

Hardy, J ;

Goate, A ;

van Swieten, J ;

Mann, D ;

Lynch, T .

NATURE, 1998, 393 (6686) :702-705

[9] The pathology of ischemic-vascular dementia: An update [J].

Jellinger, KA .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2002, 203 :153-157

[10]

KAZUYUKI O, 1999, NEUROPATHOLOGY, V19, P161

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