Anti-colony-stimulating factor therapies for inflammatory and autoimmune diseases

被引：138

作者：

Hamilton, John A. ^{[1
]}

Cook, Andrew D. ^{[1
]}

Tak, Paul P. ^{[2
]}

机构：

[1] Univ Melbourne, Royal Melbourne Hosp, Dept Med, Parkville, Vic 3050, Australia

[2] GlaxoSmithKline, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

NATURE REVIEWS DRUG DISCOVERY | 2017年 / 16卷 / 01期

基金：

英国医学研究理事会;

关键词：

COLLAGEN-INDUCED ARTHRITIS; GM-CSF RECEPTOR; ACTIVE RHEUMATOID-ARTHRITIS; HUMAN MONOCLONAL-ANTIBODY; TUMOR-ASSOCIATED MACROPHAGES; B-CELLS PROTECT; HOUSE-DUST MITE; FACTOR-I; DENDRITIC CELLS; T-CELLS;

D O I：

10.1038/nrd.2016.231

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Granulocyte macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF; also known as CSF1), granulocyte colony-stimulating factor (G-CSF) and interleukin-3 (IL-3) can each play a part in the host response to injury and infection, and there is burgeoning interest in targeting these CSFs in inflammatory and autoimmune disorders, as well as in cancer. For success in clinical medicine, therapeutic targeting will need to be delineated from current strategies. The individual CSFs have unique biological roles, suggesting that they could be used to target specific conditions. This Review compares the CSFs, with a focus on how they could be targeted, discusses the relevant clinical trial data and summarizes the potential clinical applications of targeting each CSF. Importantly, we discuss the novelty of CSF biology and attempt to clarify some of the surrounding misconceptions and issues that can affect therapeutic decisions.

引用

页码：53 / 70

页数：18

共 265 条

[1]

Granulocyte macrophage colony-stimulating factor induces CCL17 pro uction via IRF4 to mediate inflammation [J].

Achuthan, Adrian ;

Cook, Andrew D. ;

Lee, Ming-Chin ;

Saleh, Reem ;

Khiew, Hsu-Wei ;

Chang, Melody W. N. ;

Louis, Cynthia ;

Fleetwood, Andrew J. ;

Lacey, Derek C. ;

Christensen, Anne D. ;

Frye, Ashlee T. ;

Lam, Pui Yeng ;

Kusano, Hitoshi ;

Nomura, Koji ;

Steiner, Nancy ;

Foerster, Irmgard ;

Nutt, Stephen L. ;

Olshansky, Moshe ;

Turner, Stephen J. ;

Hamilton, John A. .

JOURNAL OF CLINICAL INVESTIGATION, 2016, 126 (09) :3453-3466

[2]

The CSF-1 receptor fashions the intestinal stem cell niche [J].

Akcora, Dilara ;

Huynh, Duy ;

Lightowler, Sally ;

Germann, Markus ;

Robine, Sylvie ;

de May, Jan R. ;

Pollard, Jeffrey W. ;

Stanley, E. Richard ;

Malaterre, Jordane ;

Ramsay, Robert G. .

STEM CELL RESEARCH, 2013, 10 (02) :203-212

[3]

CSF-1-dependant donor-derived macrophages mediate chronic graft-versus-host disease [J].

Alexander, Kylie A. ;

Flynn, Ryan ;

Lineburg, Katie E. ;

Kuns, Rachel D. ;

Teal, Bianca E. ;

Olver, Stuart D. ;

Lor, Mary ;

Raffelt, Neil C. ;

Koyama, Motoko ;

Leveque, Lucie ;

Le Texier, Laetitia ;

Melino, Michelle ;

Markey, Kate A. ;

Varelias, Antiopi ;

Engwerda, Christian ;

Serody, Jonathan S. ;

Janela, Baptiste ;

Ginhoux, Florent ;

Clouston, Andrew D. ;

Blazar, Bruce R. ;

Hill, Geoffrey R. ;

MacDonald, Kelli P. A. .

JOURNAL OF CLINICAL INVESTIGATION, 2014, 124 (10) :4266-4280

[4]

Intra-articular administration of an antibody against CSF-1 receptor reduces pain-related behaviors and inflammation in CFA-induced knee arthritis [J].

Alvarado-Vazquez, P. A. ;

Morado-Urbina, C. E. ;

Castaneda-Corral, G. ;

Acosta-Gonzalez, R. I. ;

Kitaura, H. ;

Kimura, K. ;

Takano-Yamamoto, T. ;

Jimenez-Andrade, J. M. .

NEUROSCIENCE LETTERS, 2015, 584 :39-44

[5]

CD123, the plasmacytoid dendritic cell phenotypic marker, is abundant in leprosy type 1 reaction [J].

Andrade, P. R. ;

Amadeu, T. P. ;

Nery, J. A. ;

Pinheiro, R. O. ;

Sarno, E. N. .

BRITISH JOURNAL OF DERMATOLOGY, 2015, 172 (01) :268-271

[6]

The IL-3/IL-5/GM-CSF common β receptor plays a pivotal role in the regulation of Th2 immunity and allergic airway inflammation [J].

Asquith, Kelly L. ;

Ramshaw, Hayley S. ;

Hansbro, Philip M. ;

Beagley, Kenneth W. ;

Lopez, Angel F. ;

Foster, Paul S. .

JOURNAL OF IMMUNOLOGY, 2008, 180 (02) :1199-1206

[7]

NADPH oxidase controls neutrophilic response to sterile inflammation in mice by regulating the IL-1α/G-CSF axis [J].

Bagaitkar, Juhi ;

Pech, Nancy K. ;

Ivanov, Stoyan ;

Austin, Anthony ;

Zeng, Melody Yue ;

Pallat, Sabine ;

Huang, Guangming ;

Randolph, Gwendalyn J. ;

Dinauer, Mary C. .

BLOOD, 2015, 126 (25) :2724-2733

[8]

Transcriptional mechanisms underlying sensitization of peripheral sensory neurons by Granulocyte-/Granulocyte-macrophage colony stimulating factors [J].

Bali, Kiran Kumar ;

Venkataramani, Varun ;

Satagopam, Venkata P. ;

Gupta, Pooja ;

Schneider, Reinhard ;

Kuner, Rohini .

MOLECULAR PAIN, 2013, 9

[9]

Basu S, 2000, BLOOD, V95, P3725

[10]

Evaluation of role of G-CSF in the production, survival, and release of neutrophils from bone marrow into circulation [J].

Basu, S ;

Hodgson, G ;

Katz, M ;

Dunn, AR .

BLOOD, 2002, 100 (03) :854-861

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