NO EVIDENCE OF VANCOMYCIN MINIMAL INHIBITORY CONCENTRATION CREEP OR HETERORESISTANCE IDENTIFIED IN PEDIATRIC STAPHYLOCOCCUS AUREUS BLOOD ISOLATES

被引:23
作者
Goldman, Jennifer L. [1 ,2 ]
Harrison, Christopher J. [1 ,2 ]
Myers, Angela L. [1 ,2 ]
Jackson, Mary Anne [1 ,2 ]
Selvarangan, Rangaraj [2 ,3 ]
机构
[1] Childrens Mercy Hosp & Clin, Div Pediat Infect Dis, Kansas City, MO 64108 USA
[2] Univ Missouri, Sch Med, Dept Med, Kansas City, MO 64108 USA
[3] Childrens Mercy Hosp & Clin, Dept Microbiol, Kansas City, MO 64108 USA
基金
美国国家卫生研究院;
关键词
Staphylococcus aureus; vancomycin; resistance; heteroresistance; BACTEREMIA; MICS;
D O I
10.1097/01.inf.0000436281.18687.0c
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
071005 [微生物学]; 100108 [医学免疫学];
摘要
We evaluated vancomycin minimum inhibitory concentration (MIC) trends by 3 methods (broth microdilution, Etest and Vitek 2) in 208 Staphylococcus aureus blood isolates from 2006 to 2009 and assessed for heteroresistance. Vancomycin MICs did not increase nor was heteroresistance identified. Etest yielded higher MIC results than the other 2 methods. No MIC was >2 mu g/mL by any testing method.
引用
收藏
页码:216 / 218
页数:3
相关论文
共 11 条
[1]
Clinical and Laboratory Standards Institute, 2009, M100S19 CLIN LAB STA
[2]
Trends in the Incidence of Methicillin-Resistant Staphylococcus aureus Infection in Children's Hospitals in the United States [J].
Gerber, Jeffrey S. ;
Coffin, Susan E. ;
Smathers, Sarah A. ;
Zaoutis, Theoklis E. .
CLINICAL INFECTIOUS DISEASES, 2009, 49 (01) :65-71
[3]
Impact of Vancomycin Exposure on Outcomes in Patients with Methicillin-Resistant Staphylococcus aureus Bacteremia: Support for Consensus Guidelines Suggested Targets [J].
Kullar, Ravina ;
Davis, Susan L. ;
Levine, Donald P. ;
Rybak, Michael J. .
CLINICAL INFECTIOUS DISEASES, 2011, 52 (08) :975-981
[4]
Evaluation of the Etest GRD for the detection of Staphylococcus aureus with reduced susceptibility to glycopeptides [J].
Leonard, Steven N. ;
Rossi, Kerri L. ;
Newton, Karly L. ;
Rybak, Michael J. .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2009, 63 (03) :489-492
[5]
Relationship between vancomycin MIC and failure among patients with methicillin-resistant Staphylococcus aureus bacteremia treated with vancomycin [J].
Lodise, T. P. ;
Graves, J. ;
Evans, A. ;
Graffunder, E. ;
Helmecke, M. ;
Lomaestro, B. M. ;
Stellrecht, K. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (09) :3315-3320
[6]
Vancomycin MICs for Staphylococcus aureus Vary by Detection Method and Have Subtly Increased in a Pediatric Population Since 2005 [J].
Mason, Edward O. ;
Lamberth, Linda B. ;
Hammerman, Wendy A. ;
Hulten, Kristina G. ;
Versalovic, James ;
Kaplan, Sheldon L. .
JOURNAL OF CLINICAL MICROBIOLOGY, 2009, 47 (06) :1628-1630
[7]
Influence of vancomycin minimum inhibitory concentration on the treatment of methicillin-resistant Staphylococcus aureus bacteremia [J].
Soriano, Alex ;
Marco, Francesc ;
Martinez, Jose A. ;
Pisos, Elena ;
Almela, Manel ;
Dimova, Veselka P. ;
Alamo, Dolores ;
Ortega, Mar ;
Lopez, Josefina ;
Mensa, Josep .
CLINICAL INFECTIOUS DISEASES, 2008, 46 (02) :193-200
[8]
Vancomycin MIC creep in non-vancomycin-intermediate Staphylococcus aureus (VISA), vancomycin-susceptible clinical methicillin-resistant S-aureus (MRSA) blood isolates from 2001-05 [J].
Steinkraus, Gregory ;
White, Roger ;
Friedrich, Lawrence .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2007, 60 (04) :788-794
[9]
Increased vancomycin MICs for Staphylococcus aureus clinical isolates from a university hospital during a 5-year period [J].
Wang, Guiqing ;
Hindler, Janet F. ;
Ward, Kevin W. ;
Bruckner, David A. .
JOURNAL OF CLINICAL MICROBIOLOGY, 2006, 44 (11) :3883-3886
[10]
Wikler M.A., 2009, METHODS DILUTION ANT, V8th ed.