Synthetic studies of trichloroleucine marine natural products.: Michael addition of LiCCl3 to N-crotonylcamphor sultam

被引：28

作者：

Brantley, SE ^{[1
]}

Molinski, TF ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 13期

关键词：

D O I：

10.1021/ol991256g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Conjugate addition of trichloromethyllithium to N-crotonylcamphorsultam occurs in good yield at -98 degrees C in THF-hexanes, The formal incorporation of the "CCl3-" anion by 1,4-addition allows subsequent transformation to useful trichloromethyl-substituted intermediates.

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页码：2165 / 2167

页数：3

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