Involvement of GATA-4/-5 transcription factors in ovarian carcinogenesis

被引：39

作者：

Wakana, Kimio

Akiyama, Yoshimitsu

Aso, Takeshi

Yuasa, Yasuhito

机构：

[1] Tokyo Med & Dent Univ, Grad Sch Med & Dent, Dept Comprehens Reprod Med, Bunkyo Ku, Tokyo 1138519, Japan

[2] Tokyo Med & Dent Univ, Grad Sch Med & Dent, Dept Mol Oncol, Bunkyo Ku, Tokyo 1138519, Japan

来源：

CANCER LETTERS | 2006年 / 241卷 / 02期

关键词：

GATA transcription factors; ovarian cancer; methylation; apoptosis;

D O I：

10.1016/j.canlet.2005.10.039

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To clarify the role of GATA transcription factors in ovarian carcinogenesis, we analyzed the expression and methylation states of GATA-4/-5/-6 in eight human ovarian cancer cell lines. GATA-4/-5 were methylated in three and two cell lines without their expression, respectively. Methylation of GATA-4/-5 was also detected in nine and five of 15 primary ovarian cancers, respectively. GATA-6 was not methylated in any cases. We transiently over-expressed GATA-5 in the JHOC-5 cell line using an adenovirus system, resulting in that apoptosis was induced and apoptosis-related genes, such as Apaf-1, were up-regulated. These data suggest that GATA-4/-5 may be involved in ovarian carcinogenesis. (c) 2006 Elsevier Ireland Ltd. All fights reserved.

引用

页码：281 / 288

页数：8

共 32 条

[1] GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer [J].