Regulatory links between PLC enzymes and Ras superfamily GTPases: Signalling via PLCε

被引：39

作者：

Bunney, Tom D. ^{[1
]}

Baxendale, Rhona W. ^{[1
]}

Katan, Matilda ^{[1
]}

机构：

[1] Inst Canc Res, Canc Res UK Ctr, Mol Biol Chester Beatty Labs, London SW3 6JB, England

来源：

ADVANCES IN ENZYME REGULATION, VOL 49 | 2009年 / 49卷

关键词：

PHOSPHOLIPASE-C-EPSILON; PHOSPHOINOSITIDE; 3-KINASE-GAMMA; EFFECTOR INTERACTIONS; CRYSTAL-STRUCTURE; CRUCIAL ROLE; DOMAINS; BINDING; C-GAMMA(2); ACTIVATION; PREDICTION;

D O I：

10.1016/j.advenzreg.2009.01.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A growing body of work implies that links between PLC isoforms, in particular PLCε, and small G-proteins from Ras superfamily could be important in regulation of a number of cellular processes. Through successful use of biochemistry and structural biology, several interactions have been characterized providing some ideas about the regulatory mechanisms. A number of signalling pathways have also been suggested that could involve direct interaction of Ras and Rho GTPases with PLCε. Importantly, several studies combining cell biology and genetics have provided new insights into functions of PLCε and highlighted the importance of this approach to extend further and consolidate currently incomplete picture regarding its roles in development and disease. © 2009 Elsevier Ltd. All rights reserved.

引用

页码：54 / 58

页数：5

共 24 条

[1] Crucial role of phospholipase CE in chemical carcinogen-induced skin tumor development [J].

Bai, YF ;

Edamatsu, H ;

Maeda, S ;

Saito, H ;

Suzuki, N ;

Satoh, T ;

Kataoka, T .

CANCER RESEARCH, 2004, 64 (24) :8808-8810

[2] IQGAP1 in cellular signaling: bridging the GAP [J].

Brown, Matthew D. ;

Sacks, David B. .

TRENDS IN CELL BIOLOGY, 2006, 16 (05) :242-249

[3] Structural and mechanistic insights into ras association domains of phospholipase C epsilon [J].

Bunney, TD ;

Harris, R ;

Gandarillas, NL ;

Josephs, MB ;

Roe, SM ;

Sorli, SC ;

Paterson, HF ;

Rodrigues-Lima, F ;

Esposito, D ;

Ponting, CP ;

Gierschik, P ;

Pearl, LH ;

Driscoll, PC ;

Katan, M .

MOLECULAR CELL, 2006, 21 (04) :495-507

[4] Phospholipase C epsilon: linking second messengers and small GTPases [J].

Bunney, Tom D. ;

Katan, Matilda .

TRENDS IN CELL BIOLOGY, 2006, 16 (12) :640-648

[5] Genetic and pharmacologic dissection of Ras effector utilization in oncogenesis [J].

Campbell, Paul M. ;

Singh, Anurag ;

Williams, Falina J. ;

Frantz, Karen ;

Uelkue, Aylin S. ;

Kelley, Grant G. ;

Der, Channing J. .

REGULATORS AND EFFECTORS OF SMALL GTPASES: RAS FAMILY, 2006, 407 :195-+

[6] Targeting ras signalling pathways in cancer therapy [J].

Downward, J .

NATURE REVIEWS CANCER, 2003, 3 (01) :11-22

[7] Always look on the bright site of Rho: structural implications for a conserved intermolecular interface [J].

Dvorsky, R ;

Ahmadian, MR .

EMBO REPORTS, 2004, 5 (12) :1130-1136

[8]

Gandarillas Natalia Lamuno, 2009, V462, P379, DOI 10.1007/978-1-60327-115-8_24

[9] Regulation of phospholipase C isozymes by Ras superfamily GTPases [J].

Harden, TK ;

Sondek, J .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2006, 46 :355-379

[10] Backbone 1H, 13C, and 15N resonance assignments for the two 13 kD Ras associating domains (RA1 and RA2) from phospholipase Cε [J].

Harris, R ;

Bunney, TD ;

Katan, M ;

Driscoll, PC .

JOURNAL OF BIOMOLECULAR NMR, 2005, 33 (02) :138-138

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