Mechanism of Iron Oxide-Induced Macrophage Activation: The Impact of Composition and the Underlying Signaling Pathway

被引：178

作者：

Gu, Zhengying ^{[1
]}

Liu, Tianqing ^{[2
]}

Tang, Jie ^{[1
]}

Yang, Yannan ^{[1
]}

Song, Hao ^{[1
]}

Tuong, Zewen K. ^{[3
]}

Fu, Jianye ^{[1
]}

Yu, Chengzhong ^{[1
,4
]}

机构：

[1] Univ Queensland, Australian Inst Bioengn & Nanotechnol, Brisbane, Qld 4072, Australia

[2] QIMR Berghofer Med Res Inst, 300 Herston Rd, Brisbane, Qld 4006, Australia

[3] Univ Queensland, Diamantina Inst, Translat Res Inst, Woolloongabba, Qld 4102, Australia

[4] East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2019年 / 141卷 / 15期

基金：

澳大利亚研究理事会;

关键词：

IN-VITRO; NANOPARTICLES; POLARIZATION; LIPOPOLYSACCHARIDE; SIZE; PROTEIN; CELLS; SHAPE; TNF;

D O I：

10.1021/jacs.8b10904

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Iron oxide nanoparticles (IONPs) have emerging anticancer applications via polarizing tumor-associated macrophages from tumor-promoting phenotype (M2) to tumor-suppressing phenotype (M1). However, the underlying mechanism and structure-function relationship remain unclear. We report magnetite IONPs are more effective compared to hematite in M1 polarization and tumor suppression. Moreover, magnetite IONPs specifically rely on interferon regulatory factor 5 signaling pathway for M1 polarization and down-regulate M2-assoicated arginase-1. This study provides new understandings and paves the way for designing advanced iron-based anticancer technologies.

引用

页码：6122 / 6126

页数：5

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