Autophagy balances inflammation in innate immunity

被引：619

作者：

Deretic, Vojo ^{[1
,2
]}

Levine, Beth ^{[3
,4
,5
]}

机构：

[1] Univ New Mexico, Hlth Sci Ctr, Autophagy Inflammat & Metab Dis AIM Ctr Biomed Re, Albuquerque, NM 87131 USA

[2] Univ New Mexico, Hlth Sci Ctr, Dept Mol Genet & Microbiol, Albuquerque, NM 87131 USA

[3] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Ctr Autophagy Res, Dallas, TX 75390 USA

[4] Univ Texas Southwestern Med Ctr Dallas, Dept Microbiol, Dallas, TX USA

[5] Univ Texas Southwestern Med Ctr Dallas, Howard Hughes Med Inst, Dallas, TX USA

来源：

AUTOPHAGY | 2018年 / 14卷 / 02期

关键词：

Autophagy; microbes mitochondria; inflamamsome; interferon; lysosome; phagosome; GENOME-WIDE ASSOCIATION; SYSTEMIC-LUPUS-ERYTHEMATOSUS; GMP-AMP SYNTHASE; SELECTIVE AUTOPHAGY; MYCOBACTERIUM-TUBERCULOSIS; DAMAGED MITOCHONDRIA; DNA SENSOR; ANTIMICROBIAL DEFENSE; IL-1-BETA PRODUCTION; LUNG INFLAMMATION;

D O I：

10.1080/15548627.2017.1402992

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Macroautophagy/autophagy is a homeostatic process with multiple effects on immunity. One of the pivotal contributions of autophagy in immunity is the cell autonomous control of inflammation. This property leads to systemic consequences and thereby influences the development of innate and adaptive immunity, which promotes or suppresses pathology in various disease contexts. In this review we focus on the intersections between autophagy and inflammasome activation, autophagy and interferons, and autophagy and inflammation in association with infection.

引用

页码：243 / 251

页数：9

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