Synthesis of novel phosphatidylcholine lipids with fatty acid chains bearing aromatic units. Generation of oxidatively stable, fluid phospholipid membranes

被引：18

作者：

Bhattacharya, S ^{[1
]}

Subramanian, M ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 23期

关键词：

D O I：

10.1016/S0040-4039(02)00758-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

The first examples of diacylphospholipid analogs, which contain aromatic units at various depths of their hydrocarbon chains, have been synthesized. The membranes produced from the sonicated aqueous suspensions of these newly synthesized lipids are oxidatively stable and possess long shelf life. These membranes maintain fluid character at ambient temperature making them ideal for membrane protein reconstitution studies. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：4203 / 4206

页数：4

共 30 条

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[Anonymous], 1993, PHOSPHOLIPID HDB

[2]

BERGELSON LD, 1980, LIPID BIOCH PREP, P125

[3]

Synthesis of macrocyclic diacyl/dialkyl glycerols containing disulfide tether and studies of their effects upon incorporation in DPPC membranes.: Implications in the design of phospholipase A2 modulators [J].