Follicular dendritic cells specifically express the long CR2/CD21 isoform

被引：115

作者：

Liu, YJ ^{[1
]}

Xu, JC ^{[1
]}

deBouteiller, O ^{[1
]}

Parham, CL ^{[1
]}

Grouard, G ^{[1
]}

Djossou, O ^{[1
]}

deSaintVis, B ^{[1
]}

Lebecque, S ^{[1
]}

Banchereau, J ^{[1
]}

Moore, KW ^{[1
]}

机构：

[1] DNAX RES INST MOL & CELLULAR BIOL INC, PALO ALTO, CA 94304 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1997年 / 185卷 / 01期

关键词：

D O I：

10.1084/jem.185.1.165

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This paper describes an antibody (mAb 7D6) that specifically recognizes human follicular dendritic cells (FDCs). By expression cloning, a cDNA clone encoding for the long human CR2/CD21 isoform (CD21L) that contains an additional exon (10a) was isolated. We demonstrated that FDCs selectively express CD21L, while B cells selectively express the short CR2/CD21 lacking exon 10a (CD21S). By screening mouse Ltk(-) cells transfected with the CD21L cDNA, we further showed that the other two anti-human FDC mAbs DRC-1 and KiM4 also recognize CD21L. Thus, CD21L represents the first characterized human FDC-specific molecule, which may confer unique functions of FDCs in germinal center development.

引用

页码：165 / 170

页数：6

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