Analysis of exhaled breath from smokers, passive smokers and non-smokers by solid-phase microextraction gas chromatography/mass spectrometry

被引：152

作者：

Buszewski, Boguslaw ^{[1
]}

Ulanowska, Agnieszka ^{[1
,2
]}

Ligor, Tomasz ^{[1
,2
]}

Denderz, Natalia ^{[1
]}

Amann, Anton ^{[2
]}

机构：

[1] Nicolaus Copernicus Univ, Fac Chem, Chair Environm Chem & Bioanalyt, PL-87100 Torun, Poland

[2] Innsbruck Med Univ, Dept Anesthesiol & Crit Med Care, A-6020 Innsbruck, Austria

来源：

BIOMEDICAL CHROMATOGRAPHY | 2009年 / 23卷 / 05期

关键词：

breath analysis; lung diseases; cigarette smoking; biomarkers; VOLATILE ORGANIC-COMPOUNDS; CRITICALLY-ILL PATIENTS; OXIDATIVE STRESS; BIOMARKERS; CANCER; MECHANISMS; EMISSIONS; BENZENE; CELLS; MS;

D O I：

10.1002/bmc.1141

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, 38 samples of expired air were collected and analyzed from 20 non-smoking volunteers, four passive smokers and 14 smokers (21 women and 17 men). Measurements were carried out using solid-phase microextraction (SPME) as an isolation and preconcentration technique. The determination and identification were accomplished by gas chromatography coupled with mass spectrometry (GC/MS). Our data showed that ca 32% of all identified compounds in the breath of healthy non-smokers were saturated hydrocarbons. In the breath of smoking and passive smoking volunteers hydrocarbons were predominant, but also present were more exogenous analytes such as furan, acetonitrile and benzene than in the breath of non-smokers. Acetonitrile, furan, 3-methylfuran, 2,5-dimethylfuran, 2-butanone, octane and decane were identified in breath of smoking and passive smoking persons. Copyright (C) 2008 John Wiley & Sons, Ltd.

引用

页码：551 / 556

页数：6

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