Development of gonadotropin-releasing hormone-1 neurons

被引：105

作者：

Wray, S ^{[1
]}

机构：

[1] NINDS, Cellular & Dev Neurobiol Sect, NIH, Bethesda, MD 20892 USA

来源：

FRONTIERS IN NEUROENDOCRINOLOGY | 2002年 / 23卷 / 03期

关键词：

D O I：

10.1016/S0091-3022(02)00001-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Gonadotropin releasing hormone-1 (GnRH-1) neurons, critical for reproduction, are derived from the nasal placode and migrate into the brain during prenatal development. Once within the brain, GnRH-1 cells become integral components of the CNS-pituitary-gonadal axis, essential for reproductive maturation and maintenance of reproductive function in adults. This review focuses on the lineage and development of the GnRH-1 neuroendocrine system. Although the migration of these cells from nose to brain has been well documented in a variety of species, many questions remain concerning the molecules and cues directing GnRH-1 cell differentiation, migration, axon targeting, and establishment and control of GnRH-1 secretion. These processes most likely involve multiple and redundant cues because if these mechanisms fail, reproduction dysfunction will ensue and guarantee that this defect does not remain in the gene pool.

引用

页码：292 / 316

页数：25

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