Isolation and synthesis of analgesic and anti-inflammatory compounds from Ochna squarrosa L.

被引：47

作者：

Anuradha, V.

Srinivas, Pullela V.

Rao, R. Ranga

Manjulatha, K.

Purohit, Muralidhar G.

Rao, J. Madhusudana ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Nat Prod Lab, Div Organ 1, Hyderabad 500007, Andhra Pradesh, India

[2] Univ Gulbarga, Dept Chem, Gulbarga, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 20期

关键词：

Ochna squarrosa; furanoflavanoid; chalcone dimer; analgesic activity; anti-inflammatory activity;

D O I：

10.1016/j.bmc.2006.06.048

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new furanoflavonoids (1, 2), one new chalcone dimer (3) along with six known compounds, chrysophanol, 5-O-methyl squarrosin, 5-methoxy furano[4",5",6,7]flavone, calodenone, lophirone A and lophirone H were isolated from the ethyl acetate-soluble fraction of methanol extract of root bark of Ochna squarrosa. Chrysophanol, calodenone, lophirone A and lophirone H were isolated from this plant for the first time. The structures of all the isolated compounds were confirmed by 1D and 2D spectroscopic data. These compounds were tested for analgesic and anti-inflammatory activity. All the new compounds showed good analgesic and anti-inflammatory activity. A simple and facile method for the cleavage of benzyl ethers using I-2 in trigol is also reported. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：6820 / 6826

页数：7

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