The mechanism and function of circular RNAs in human diseases

被引：132

作者：

Lei, Kexin ^{[1
]}

Bai, Hetian ^{[1
]}

Wei, Zihao ^{[1
]}

Xie, Changqing ^{[2
]}

Wang, Jiongke ^{[1
]}

Li, Jing ^{[1
]}

Chen, Qianming ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp Sromatol, Natl Clin Res Ctr Oral Dis, State Key Lab Oral Dis, Chengdu, Sichuan, Peoples R China

[2] Cent South Univ, Xiangya Sromatol Hosp, Changsha, Hunan, Peoples R China

来源：

EXPERIMENTAL CELL RESEARCH | 2018年 / 368卷 / 02期

基金：

中国国家自然科学基金;

关键词：

CircRNA; Biology function; Central neural system diseases; Cardiovascular diseases; Cancer; CASPASE RECRUITMENT DOMAIN; BREAST-CANCER; APOPTOSIS REPRESSOR; CELL-PROLIFERATION; NONCODING RNAS; EXPRESSION; BIOMARKER; INVASION; REVEALS; PROFILE;

D O I：

10.1016/j.yexcr.2018.05.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Circular RNAs (circRNAs) are a recently discovered form of RNA. Initially, circRNAs were believed to result from errors during the process of gene transcription. However, after further investigation, scientists suggested that circRNAs are of great biological significance. CircRNAs show stability, conservation, abundance, and tissue and stage specificity. They can also function as miRNA sponges, regulate gene expression, and interact with proteins to affect cell behavior. Emerging evidence has also demonstrated that circRNAs participate or show abnormal expression in diseases, including central nervous system diseases, cardiovascular diseases and cancers, indicating their marked potential in the prediction and prognosis of diseases and clinical treatment.

引用

页码：147 / 158

页数：12

共 130 条

[1]

Abelson J., 1998, TRNA SPLICING

[2]

The State State of Lung Cancer Research: A Global Analysis [J].