Targeting lymphocyte activation to treat rheumatoid arthritis

被引：32

作者：

Falgarone, Geraldine ^{[1
,2
]}

Semerano, Luca ^{[1
,2
]}

Rulle, Sandrine ^{[2
]}

Boissier, Marie-Christophe ^{[1
,2
]}

机构：

[1] Avicenne Teaching Hosp, APHP, Dept Rheumatol, F-93009 Bobigny, France

[2] Univ Paris 13, Li2P, EA4222, Bobigny, France

来源：

JOINT BONE SPINE | 2009年 / 76卷 / 04期

关键词：

Rheumatoid arthritis; T-cell/antigen-presenting cell interactions; Abatacept; COSTIMULATION MODULATOR ABATACEPT; REGULATORY T-CELLS; DENDRITIC CELLS; INNATE IMMUNITY; ALPHA-CHAINS; DOUBLE-BLIND; AUTOANTIBODIES; METAANALYSIS; SYNOVITIS; DISEASE;

D O I：

10.1016/j.jbspin.2008.12.007

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The introduction of targeted treatments has radically changed the management of patients with rheumatoid arthritis (RA). Abatacept is among these new treatments emerging from recent insights into joint immunopathology. Abatacept blocks the interaction between antigen-presenting cells and T-cells, thereby diminishing T-cell activation and possibly improving overall cell regulation. In RA patients, abatacept is effective in decreasing the arthritis, pain, disability, fatigue, and radiological joint damage. Abatacept provides lasting remissions or low levels of disease activity and therefore constitutes a valuable addition to the current therapeutic armamentarium for RA, which is hoped to make a full remission an attainable goal in the overall population of RA patients. (C) 2009 Societe Francaise de Rhumatologie. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：327 / 332

页数：6

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