ABCG4: a novel human white family ABC-transporter expressed in the brain and eye

被引：46

作者：

Oldfield, S ^{[1
]}

Lowry, CA ^{[1
]}

Ruddick, J ^{[1
]}

Lightman, SL ^{[1
]}

机构：

[1] Univ Bristol, Bristol Royal Infirm, Univ Res Ctr Neuroendocrinol, Bristol BS2 8HW, Avon, England

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2002年 / 1591卷 / 1-3期

基金：

英国医学研究理事会;

关键词：

white gene; ABC-transporter; ABCG1; sterol;

D O I：

10.1016/S0167-4889(02)00269-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

White family transporters are a group of ATP-binding cassette (ABC) proteins that show sequence homology to the Drosophila white gene product. The Drosophila protein is a subunit of heterodimeric transporters of precursors for eye-pigment synthesis. A novel, human member of this family (ABCG4) has been identified. Northern blotting shows that ABCG4 is expressed specifically in the brain and the eye. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：175 / 179

页数：5

共 23 条

[1] Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters [J].

Berge, KE ;

Tian, H ;

Graf, GA ;

Yu, LQ ;

Grishin, NV ;

Schultz, J ;

Kwiterovich, P ;

Shan, B ;

Barnes, R ;

Hobbs, HH .

SCIENCE, 2000, 290 (5497) :1771-1775

[2]

Chen HM, 1996, AM J HUM GENET, V59, P66

[3] Isolation and characterization of a mammalian homolog of the Drosophila white gene [J].

Croop, JM ;

Tiller, GE ;

Fletcher, JA ;

Lux, ML ;

Raab, E ;

Goldenson, D ;

Son, D ;

Arciniegas, S ;

Wu, RL .

GENE, 1997, 185 (01) :77-85

[4] A multidrug resistance transporter from human MCF-7 breast cancer cells [J].

Doyle, LA ;

Yang, WD ;

Abruzzo, LV ;

Krogmann, T ;

Gao, YM ;

Rishi, AK ;

Ross, DD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (26) :15665-15670

[5] THE BROWN PROTEIN OF DROSOPHILA-MELANOGASTER IS SIMILAR TO THE WHITE PROTEIN AND TO COMPONENTS OF ACTIVE-TRANSPORT COMPLEXES [J].

DREESEN, TD ;

JOHNSON, DH ;

HENIKOFF, S .

MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (12) :5206-5215

[6] The human ABCG4 gene is regulated by oxysterols and retinoids in monocyte-derived macrophages [J].

Engel, T ;

Lorkowski, S ;

Lueken, A ;

Rust, S ;

Schlüter, B ;

Berger, G ;

Cullen, P ;

Assmann, G .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 288 (02) :483-488

[7]

EWART GD, 1994, J BIOL CHEM, V269, P10370

[8] ABC-ATPases, adaptable energy generators fuelling transmembrane movement of a variety of molecules organisms from bacteria to humans [J].

Holland, IB ;

Blight, MA .

JOURNAL OF MOLECULAR BIOLOGY, 1999, 293 (02) :381-399

[9] Characterization of the human ABCG1 gene - Liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein [J].

Kennedy, MA ;

Venkateswaran, A ;

Tarr, PT ;

Xenarios, I ;

Kudoh, J ;

Shimizu, N ;

Edwards, PA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (42) :39438-39447

[10] ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport [J].

Klucken, J ;

Büchler, C ;

Orsó, E ;

Kaminski, WE ;

Porsch-Özcürümez, M ;

Liebisch, C ;

Kapinsky, M ;

Diederich, W ;

Drobnik, W ;

Dean, M ;

Allikmets, R ;

Schmitz, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (02) :817-822

← 1 2 3 →