NAFLD leads to liver cancer: Do we have sufficient evidence?

被引：91

作者：

Duan, Xiao-Yan ^{[1
]}

Zhang, Lei ^{[2
]}

Fan, Jian-Gao ^{[1
]}

Qiao, Liang ^{[3
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Key Lab Childrens Digest & Nutr, Dept Gastroenterol, Xinhua Hosp,Sch Med, Shanghai 200092, Peoples R China

[2] Lanzhou Univ, Hosp 1, Dept Gen Surg, Lanzhou 730000, Gansu, Peoples R China

[3] Westmead Millennium Inst, Univ Sydney, Storr Liver Unit, Westmead, NSW 2145, Australia

来源：

CANCER LETTERS | 2014年 / 345卷 / 02期

基金：

澳大利亚国家健康与医学研究理事会; 中国国家自然科学基金;

关键词：

Fatty liver; Nonalcoholic steatohepatitis; Liver cancer; Hepatocellular carcinoma; NONALCOHOLIC FATTY LIVER; TERM-FOLLOW-UP; HEPATOCELLULAR-CARCINOMA; NATURAL-HISTORY; RISK-FACTORS; DIABETES-MELLITUS; CRYPTOGENIC CIRRHOSIS; METABOLIC SYNDROME; CLINICAL-FEATURES; IRON OVERLOAD;

D O I：

10.1016/j.canlet.2013.07.033

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Primary liver cancer has several well-recognized risk factors, such as HBV and HCV infection, alcohol abuse and aflatoxin. Recent studies show that nonalcoholic fatty liver disease (NAFLD), especially its aggressive form nonalcoholic steatohepatitis (NASH) is associated with an increased risk of liver cancer, mainly hepatocellular carcinoma (HCC). On the other hand, clinical and epidemiological data have showed that HCC has rarely been found in a "pure" fatty liver in human. Thus, the question we need to ask is do we have sufficient evidence to support a causative role of NAFLD in liver cancer? Furthermore, if NAFLD is indeed a causative factor for liver cancer, what is the mechanism? Perhaps at this stage, fatty liver and NASH can be regarded as a definite risk factor for liver cancer, but to conclude that NAFLD induces HCC requires more robust in vitro and in vivo data. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：230 / 234

页数：5

共 87 条

[1]

Abergel Armand, 2006, Rev Prat, V56, P2130

[2]

The natural history of nonalcoholic fatty liver disease: A population-based cohort study [J].