Clinicopathological significance of vascular endothelial growth factor-C and cyclooxygenase-2 in esophageal squamous cell carcinoma

被引:29
作者
Byeon, JS
Jung, HY
Lee, YJ
Lee, D
Lee, GH
Myung, SJ
Yang, SK
Hong, WS
Kim, JH
Min, YI
Kim, JS
机构
[1] Univ Ulsan Coll Med, Asan Med Ctr, Div Gastroenterol, Dept Internal Med, Seoul 138736, South Korea
[2] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Diagnost Pathol, Seoul, South Korea
关键词
cyclooxygenase-2; endoscopic mucosal resection; esophageal squamous cell carcinoma; vascular endothelial growth factor-C;
D O I
10.1111/j.1440-1746.2004.03348.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: Vascular endothelial growth factor-C (VEGF-C) is a specific growth factor of lymphatics, which is known to play some role in tumor growth and metastasis to lymph nodes and distant organs in various malignancies. The purpose of the present study was to investigate the expression of VEGF-C in human esophageal squamous cell carcinomas (ESCC) to elucidate its role in tumor progression and lymph node metastasis. Another aim of the study was to investigate the relation between VEGF-C and cyclooxygenase-2 (COX-2) in ESCC. Methods: The expression of VEGF-C and COX-2 in ESCC was evaluated in 13 endoscopic mucosal resection specimens and in 21 surgical specimens by immunohistochemical staining. Clinical data were obtained from medical records. Results: The degree of VEGF-C expression increased as the depth of primary tumor progressed (r = 0.521, P = 0.002), the stage progressed (r = 0.572, P < 0.001), and the degree of COX-2 expression increased (r = 0.387, P = 0.024). The VEGF-C positive rate was different between early cancers in which regional lymph node metastasis was thought to be absent and advanced cancers in which regional lymph node metastases were confirmed after surgery (20.0% vs 100.0%; P < 0.001). Conclusions: The VEGF-C expression in ESCC is related to COX-2 expression, and VEGF-C is also associated with the depth of primary tumor, the stage, and probably lymph node metastasis. Thus the investigation of VEGF-C expression in ESCC may assist in management planning. (C) 2004 Blackwell Publishing Asia Pty Ltd.
引用
收藏
页码:648 / 654
页数:7
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