Heat shock protein 27 in neuronal survival and neurite outgrowth

被引：46

作者：

Read, Danielle E.

Gorman, Adrienne M. ^{[1
]}

机构：

[1] Natl Univ Ireland, Cell Death & Survival Grp, Dept Biochem, Sch Nat Sci, Galway, Ireland

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 382卷 / 01期

关键词：

Akt; Cell death; Neurodegeneration; Neuroregeneration; ALPHA-B-CRYSTALLIN; MARIE-TOOTH-DISEASE; INDUCED CELL-DEATH; NERVE INJURY; PC12; CELLS; NEURODEGENERATIVE DISEASES; MOTOR-NEURONS; UP-REGULATION; IN-VITRO; HSP27;

D O I：

10.1016/j.bbrc.2009.02.114

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The small heat shock protein 27 (Hsp27) is well documented to promote neuronal survival in neurodegenerative diseases and following nerve injury. It can directly inhibit apoptotic pathways, and as a chaperone it can ameliorate the toxic effects of misfolded proteins. More recently, Hsp27 has been implicated to also play a role in neurite outgrowth. Thus, Hsp27 is situated at the intersection of neuronal survival and differentiation and, as such, it has dual potential as a key therapeutic target for neuroregeneration. (C) 2009 Elsevier Inc. All rights reserved.

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页码：6 / 8

页数：3

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