Breast Percent Density: Estimation on Digital Mammograms and Central Tomosynthesis Projections

被引:55
作者
Bakic, Predrag R. [1 ]
Carton, Ann-Katherine [1 ]
Kontos, Despina [1 ]
Zhang, Cuiping [1 ]
Troxel, Andrea B. [2 ]
Maidment, Andrew D. A. [1 ]
机构
[1] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA
关键词
CANCER RISK; FEATURES; WOMEN; DIET; ASSOCIATIONS; TAMOXIFEN; PATTERNS; TISSUE; MODEL;
D O I
10.1148/radiol.2521081621
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: To evaluate inter- and intrareader agreement in breast percent density (PD) estimation on clinical digital mammograms and central digital breast tomosynthesis (DBT) projection images. Materials and Methods: This HIPAA-compliant study had institutional review board approval; all patients provided informed consent. Breast PD estimation was performed on the basis of anonymized digital mammograms and central DBT projections in 39 women ( mean age, 51 years; range, 31-80 years). All women had recently detected abnormalities or biopsyproved cancers. PD was estimated by three experienced readers on the mediolateral oblique views of the contralateral breasts by using software; each reader repeated the estimation after 2 months. Spearman correlations of inter- and intrareader and intermodality PD estimates, as well as kappa statistics between categoric PD estimates, were computed. Results: High correlation (rho = 0.91) was observed between PD estimates on digital mammograms and those on central DBT projections, averaged over all estimations; the corresponding kappa coefficient (0.79) indicated substantial agreement. Mean interreader agreement for PD estimation on central DBT projections (rho = 0.85 +/- 0.05 [standard deviation]) was significantly higher (P < .01) than that for PD estimation on digital mammograms (rho = 0.75 +/- 0.05); the corresponding kappa coefficients indicated substantial (kappa = 0.65 +/- 0.12) and moderate (kappa = 0.55 +/- 0.14) agreement for central DBT projections and digital mammograms, respectively. Conclusion: High correlation between PD estimates on digital mammograms and those on central DBT projections suggests the latter could be used until a method for PD estimation based on three-dimensional reconstructed images is introduced. Moreover, clinical PD estimation is possible with reduced radiation dose, as each DBT projection was acquired by using about 22% of the dose for a single mammographic projection.
引用
收藏
页码:40 / 49
页数:10
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