Differentiation and function of pro-inflammatory Th17 cells

被引：103

作者：

Dong, Chen ^{[1
]}

机构：

[1] Univ Texas Houston, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA

来源：

MICROBES AND INFECTION | 2009年 / 11卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Helper T cells; Cytokines; Inflammation; Autoimmunity; ARYL-HYDROCARBON RECEPTOR; T-CELLS; CUTTING EDGE; AUTOIMMUNE INFLAMMATION; ROR-GAMMA; TGF-BETA; PROINFLAMMATORY IL-17(+); SIGNAL-TRANSDUCTION; INTERLEUKIN; 17; HELPER-CELLS;

D O I：

10.1016/j.micinf.2009.04.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

After activation, CD4+ helper T (Th) cells differentiate into cytokine-secreting effector subsets. A novel subset of CD4+ helper T (Th) cells that produce two related cytokines IL-17 and IL-17F has been recently identified and shown to play critical function in inflammation and autoimmunity. Here I summarize recent work by us as well as other investigators in understanding the transcriptional regulation of Th17-cell differentiation, their developmental relationship with regulatory T cells and the function of IL-17 and IL-17F in vivo. (C) 2009 Elsevier Masson SAS. All fights reserved.

引用

页码：584 / 588

页数：5

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