A liquid-phase peptide synthesis in cyclohexane-based biphasic thermomorphic systems

被引：50

作者：

Chiba, K ^{[1
]}

Kono, Y ^{[1
]}

Kim, S ^{[1
]}

Nishimoto, K ^{[1
]}

Kitano, Y ^{[1
]}

Tada, M ^{[1
]}

机构：

[1] Tokyo Univ Agr & Technol, Bioorgan Chem Lab, Tokyo 1838509, Japan

来源：

CHEMICAL COMMUNICATIONS | 2002年 / 16期

关键词：

D O I：

10.1039/b205156g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Combinations of typical organic solvents composed of cyclohexane and qualified aprotic polar organic solvents were found to realize an effecitive, biphasic thermomorphic system in arbitrary ratios of upper and lower phases that enable a practical application of a liquid-phase peptide synthesis.

引用

收藏

页码：1766 / 1767

页数：2

相关论文

共 32 条

[1] Multiple-component condensation strategies for combinatorial library synthesis [J].

Armstrong, RW ;

Combs, AP ;

Tempest, PA ;

Brown, SD ;

Keating, TA .

ACCOUNTS OF CHEMICAL RESEARCH, 1996, 29 (03) :123-131

[2] Palladium-catalyzed C-C coupling under thermomorphic conditions [J].

Bergbreiter, DE ;

Osburn, PL ;

Wilson, A ;

Sink, EM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (38) :9058-9064

[3]

BERGBREITER DE, J AM CHEM COMMUN, V123, P11105

[4] Solid-supported reagent strategies for rapid purification of combinatorial synthesis products [J].

Booth, RJ ;

Hodges, JC .

ACCOUNTS OF CHEMICAL RESEARCH, 1999, 32 (01) :18-26

[5] Electrocatalytic intermolecular olefin cross-coupling by anodically induced formal [2+2] cycloaddition between enol ethers and alkenes [J].

Chiba, K ;

Miura, T ;

Kim, S ;

Kitano, Y ;

Tada, M .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (45) :11314-11315

[6] Electrochemical synthesis of chroman and euglobal skeletons via cycloaddition reaction of o-quinone methides and alkenes [J].

Chiba, K ;

Sonoyama, J ;

Tada, M .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1996, (12) :1435-1443

[7] DIELS-ALDER REACTION OF QUINONES GENERATED IN-SITU BY ELECTROCHEMICAL OXIDATION IN LITHIUM PERCHLORATE-NITROMETHANE [J].

CHIBA, K ;

TADA, M .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1994, (21) :2485-2486

[8] Fluorous biphase systems - The new phase-separation and immobilization technique [J].

Cornils, B .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1997, 36 (19) :2057-2059

[9] Tris(2-(perfluorohexyl)ethyl)tin hydride: A new fluorous reagent for use in traditional organic synthesis and liquid phase combinatorial synthesis [J].

Curran, DP ;

Hadida, S .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (10) :2531-2532

[10] Design, synthesis, and evaluation of small-molecule libraries [J].

Ellman, JA .

ACCOUNTS OF CHEMICAL RESEARCH, 1996, 29 (03) :132-143

← 1 2 3 4 →