Common mechanisms of PIKK regulation

被引：253

作者：

Lovejoy, Courtney A. ^{[1
]}

Cortez, David ^{[1
]}

机构：

[1] Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37232 USA

来源：

DNA REPAIR | 2009年 / 8卷 / 09期

关键词：

ATR; ATM; DNA-PK; mTOR; SMG1; PIKK; REPLICATION PROTEIN-A; DNA-DAMAGE CHECKPOINT; DOUBLE-STRAND BREAKS; ATM ACTIVATION; CATALYTIC SUBUNIT; MRE11; COMPLEX; ATRIP; KINASE; AUTOPHOSPHORYLATION; TOPBP1;

D O I：

10.1016/j.dnarep.2009.04.006

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

Kinases in the phosphoinositide three-kinase-related kinase (PIKK) family include ATM (ataxia-telangiectasia mutated), ATR (ATM- and Rad3-related), DNA-PKcs (DNA-dependent protein kinase catalytic subunit), mTOR (mammalian target of rapamycin), and SMG1 (suppressor with morphological effect on genitalia family member). These atypical protein kinases regulate DNA damage responses, nutrient-dependent signaling, and nonsense-mediated mRNA decay. This review focuses on the mechanisms regulating the PIKK family with a strong emphasis on the DNA damage regulated kinases. We outline common regulatory themes and suggest how discoveries about the regulation of one PIKK can be informative for the other family members. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：1004 / 1008

页数：5

共 64 条

[1]

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation [J].

Bakkenist, CJ ;

Kastan, MB .

NATURE, 2003, 421 (6922) :499-506

[2]

Function of a conserved checkpoint recruitment domain in ATRIP proteins [J].

Ball, Heather L. ;

Ehrhardt, Mark R. ;

Mordes, Daniel A. ;

Glick, Gloria G. ;

Chazin, Walter J. ;

Cortez, David .

MOLECULAR AND CELLULAR BIOLOGY, 2007, 27 (09) :3367-3377

[3]

ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation [J].

Ball, HL ;

Myers, JS ;

Cortez, D .

MOLECULAR BIOLOGY OF THE CELL, 2005, 16 (05) :2372-2381

[4]

ATRIP oligomerization is required for ATR-dependent checkpoint signaling [J].

Ball, HL ;

Cortez, D .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (36) :31390-31396

[5]

Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair [J].

Berkovich, Elijahu ;

Monnat, Raymond J., Jr. ;

Kastan, Michael B. .

NATURE CELL BIOLOGY, 2007, 9 (06) :683-U137

[6]

Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro [J].

Bermudez, VP ;

Lindsey-Boltz, LA ;

Cesare, AJ ;

Maniwa, Y ;

Griffith, JD ;

Hurwitz, J ;

Sancar, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (04) :1633-1638

[7]

Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage [J].

Bonilla, Carla Yaneth ;

Melo, Justine Amy ;

Toczyski, David Paul .

MOLECULAR CELL, 2008, 30 (03) :267-276

[8]

FAT: a novel domain in PIK-related kinases [J].

Bosotti, R ;

Isacchi, A ;

Sonnhammer, ELL .

TRENDS IN BIOCHEMICAL SCIENCES, 2000, 25 (05) :225-227

[9]

Brown EJ, 2000, GENE DEV, V14, P397

[10]

Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance [J].

Brown, EJ ;

Baltimore, D .

GENES & DEVELOPMENT, 2003, 17 (05) :615-628

← 1 2 3 4 5 6 7 →