Molecular mechanisms of hepatic fibrosis and principles of therapy

被引:238
作者
Friedman, SL [1 ]
机构
[1] UNIV CALIF SAN FRANCISCO,SCH MED,SAN FRANCISCO,CA 94143
关键词
stellate cells; hepatic fibrosis; cirrhosis; cytokiners;
D O I
10.1007/BF02934504
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Tremendous insights into the understanding of hepatic fibrosis have taken place over the past ten years. Foremost among these is the recognition that hepatic stellate cells (formerly known as lipocytes, Ito cells, or fat-storing cells) play a central role based on their ability to undergo activation following liver injury of any cause. Stellate cell activation is a broad phenotypic response, characterized by distinct functional changes in proliferation. contractility, fibrogenesis, cytokine secretion, and matrix degradation. Insights gained into the molecular regulation of hepatic stellate cell activation will lead to new, targeted approaches to hepatic fibrosis in the future? and could lead to reduced morbidity and mortality in patients with chronic liver injury.
引用
收藏
页码:424 / 430
页数:7
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