Single-molecule protein encapsulation in a rigid DNA cage

被引：229

作者：

Erben, Christoph M. ^{[1
]}

Goodman, Russell P. ^{[1
]}

Turberfield, Andrew J. ^{[1
]}

机构：

[1] Univ Oxford, Dept Phys, Clarendon Lab, Oxford OX1 3PU, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 44期

基金：

英国工程与自然科学研究理事会;

关键词：

cytochrome c; DNA structures; host-guest systems; molecular devices; self-assembly;

D O I：

10.1002/anie.200603392

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Behind bars: A single molecule of the protein cytochrome c has been incarcerated within a rigid tetrahedral DNA cage (see picture). The central cavity is estimated to be large enough to accommodate a sphere of approximately 2.6 nm in radius, such as a 60-kDa globular protein (Mr of cytochrome c: 12.4 kDa). The finding demonstrates the potential of DNA containers as a new kind of drug-delivery system. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7414 / 7417

页数：4

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