Single-molecule protein encapsulation in a rigid DNA cage

被引:229
作者
Erben, Christoph M. [1 ]
Goodman, Russell P. [1 ]
Turberfield, Andrew J. [1 ]
机构
[1] Univ Oxford, Dept Phys, Clarendon Lab, Oxford OX1 3PU, England
基金
英国工程与自然科学研究理事会;
关键词
cytochrome c; DNA structures; host-guest systems; molecular devices; self-assembly;
D O I
10.1002/anie.200603392
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
(Figure Presented) Behind bars: A single molecule of the protein cytochrome c has been incarcerated within a rigid tetrahedral DNA cage (see picture). The central cavity is estimated to be large enough to accommodate a sphere of approximately 2.6 nm in radius, such as a 60-kDa globular protein (Mr of cytochrome c: 12.4 kDa). The finding demonstrates the potential of DNA containers as a new kind of drug-delivery system. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码:7414 / 7417
页数:4
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