Sequencing and Analyses of All Known Human Rhinovirus Genomes Reveal Structure and Evolution

被引:343
作者
Palmenberg, Ann C. [2 ]
Spiro, David [3 ]
Kuzmickas, Ryan [3 ]
Wang, Shiliang [3 ]
Djikeng, Appolinaire [3 ]
Rathe, Jennifer A. [1 ]
Fraser-Liggett, Claire M. [4 ]
Liggett, Stephen B. [1 ]
机构
[1] Univ Maryland, Sch Med, Cardiopulm Genom Program, Baltimore, MD 21201 USA
[2] Univ Wisconsin, Inst Mol Virol, Madison, WI 53706 USA
[3] J Craig Venter Inst, Rockville, MD 20850 USA
[4] Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA
关键词
ASTHMA; RECOMBINATION; INFECTIONS; FEATURES; VIRUSES; TRACT;
D O I
10.1126/science.1165557
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Infection by human rhinovirus (HRV) is a major cause of upper and lower respiratory tract disease worldwide and displays considerable phenotypic variation. We examined diversity by completing the genome sequences for all known serotypes (n = 99). Superimposition of capsid crystal structure and optimal-energy RNA configurations established alignments and phylogeny. These revealed conserved motifs; clade-specific diversity, including a potential newly identified species (HRV-D); mutations in field isolates; and recombination. In analogy with poliovirus, a hypervariable 5' untranslated region tract may affect virulence. A configuration consistent with nonscanning internal ribosome entry was found in all HRVs and may account for rapid translation. The data density from complete sequences of the reference HRVs provided high resolution for this degree of modeling and serves as a platform for full genome-based epidemiologic studies and antiviral or vaccine development.
引用
收藏
页码:55 / 59
页数:5
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