Huntingtin's critical cleavage

被引：9

作者：

Fryer, John D. ^{[1
]}

Zoghbi, Huda Y.

机构：

[1] Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Mol & Human Genet, Program Dev Biol, Howard Hughes Med Inst, Houston, TX 77030 USA

来源：

NATURE NEUROSCIENCE | 2006年 / 9卷 / 09期

关键词：

D O I：

10.1038/nn0906-1088

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The early pathogenic events leading to neurodegeneration in Huntington disease are not clear. A recent paper shows that mutating a caspase-6 cleavage site in the huntingtin protein is sufficient to prevent pathogenesis.

引用

页码：1088 / 1089

页数：3

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