HCV NS5B Polymerase Inhibitors

被引：53

作者：

Burton, James R., Jr. ^{[1
]}

Everson, Gregory T. ^{[1
]}

机构：

[1] Univ Colorado Denver, Div Gastroenterol & Hepatol, Dept Med, Aurora, CO 80045 USA

来源：

CLINICS IN LIVER DISEASE | 2009年 / 13卷 / 03期

关键词：

Hepatitis C; Polymerase inhibitors; Antiviral therapy; Clinical trials; Nucleoside analog; Non-nucleoside analog; HEPATITIS-C VIRUS; ALPHA-2A PLUS RIBAVIRIN; ANTIVIRAL ACTIVITY; PEGINTERFERON ALPHA-2A; IN-VITRO; PEG-IFN; NUCLEOSIDE ANALOG; POTENT INHIBITOR; SAFETY; R7128;

D O I：

10.1016/j.cld.2009.05.001

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Chronic hepatitis C virus (HCV) infection affects approximately 4 million persons and is the major indication for liver transplantation in the United States. The current standard for treatment of HCV is pegylated interferon in combination with ribavirin. Despite significant advances in treatment, only approximately 50% of patients of treated patients clear HCV infection. Polymerase inhibitors, given their potent antiviral effects, represent a major contribution to the future of HCV treatment. Whether these new drugs will have a role in the treatment of the difficult patient (non-responders, those co-infected with HIV, decompensated liver disease and liver transplant recipients) remains to be determined.

引用

页码：453 / +

页数：14

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