Molecular Targets of Nutraceuticals Derived from Dietary Spices: Potential Role in Suppression of Inflammation and Tumorigenesis

被引：141

作者：

Aggarwal, Bharat B. ^{[1
]}

Van Kuiken, Michelle E. ^{[1
]}

Iyer, Laxmi H. ^{[1
]}

Harikumar, Kuzhuvelil B. ^{[1
]}

Sung, Bokyung ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Cytokine Res Lab, Houston, TX 77030 USA

来源：

EXPERIMENTAL BIOLOGY AND MEDICINE | 2009年 / 234卷 / 08期

基金：

美国国家卫生研究院;

关键词：

nutraceuticals; spices; inflammation; cancer; apoptosis; invasion; angiogenesis; FACTOR-KAPPA-B; CELL-CYCLE ARREST; TUMOR-NECROSIS-FACTOR; BREAST-CANCER CELLS; ACID INHIBITS ANGIOGENESIS; GINGER ZINGIBER-OFFICINALE; GARLIC ALLIUM-SATIVUM; BCL-2 FAMILY PROTEINS; MOUSE MELANOMA-CELLS; HUMAN LEUKEMIA-CELLS;

D O I：

10.3181/0902-MR-78

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Despite the fact cancer is primarily a preventable disease, recent statistics indicate cancer will become the number one killer worldwide in 2010. Since certain cancers are more prevalent in the people of some countries than others, suggests the role of lifestyle. For instance cancer incidence among people from the Indian subcontinent, where most spices are consumed, is much lower than that in the Western World. Spices have been consumed for centuries for a variety of purposes-as flavoring agents, colorants, and preservatives. However, there is increasing evidence for the importance of plant-based foods in regular diet to lowering the risk of most chronic diseases, so spices are now emerging as more than just flavor aids, but as agents that can not only prevent but may even treat disease. In this article, we discuss the role of 41 common dietary spices with over 182 spice-derived nutraceuticals for their effects against different stages of tumorigenesis. Besides suppressing inflammatory pathways, spice-derived nutraceuticals can suppress survival, proliferation, invasion, and angiogenesis of tumor cells. We discuss how spice-derived nutraceuticals mediate such diverse effects and what their molecular targets are. Overall our review suggests "adding spice to your life" may serve as a healthy and delicious way to ward off cancer and other chronic diseases. Exp Biol Med 234:825-849, 2009

引用

页码：825 / 849

页数：25

共 223 条

[1] Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe [J].

Aggarwal, Bharat B. ;

Vijayalekshmi, R. V. ;

Sung, Bokyung .

CLINICAL CANCER RESEARCH, 2009, 15 (02) :425-430

[2]

Ahmed N, 2001, ANTICANCER RES, V21, P3519

[3]

Amati Bruno, 1998, Frontiers in Bioscience, V3, pD250

[4] Cancer is a Preventable Disease that Requires Major Lifestyle Changes [J].

Anand, Preetha ;

Kunnumakara, Ajaikumar B. ;

Sundaram, Chitra ;

Harikumar, Kuzhuvelil B. ;

Tharakan, Sheeja T. ;

Lai, Oiki S. ;

Sung, Bokyung ;

Aggarwal, Bharat B. .

PHARMACEUTICAL RESEARCH, 2008, 25 (09) :2097-2116

[5] Capsaicin modulates pulmonary antioxidant defense system during benzo(a)pyrene-induced lung cancer in Swiss albino mice [J].

Anandakumar, P. ;

Kamaraj, S. ;

Jagan, S. ;

Ramakrishnan, G. ;

Vinodhkumar, R. ;

Devaki, T. .

PHYTOTHERAPY RESEARCH, 2008, 22 (04) :529-533

[6]

Aratanechemuge Y, 2002, INT J MOL MED, V9, P481

[7]

Atsumi T, 2000, ANTICANCER RES, V20, P2519

[8] Phytosterols reduce in vitro metastatic ability of MDA-MB-231 human breast cancer cells [J].

Awad, AB ;

Williams, H ;

Fink, CS .

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2001, 40 (02) :157-164

[9] COX-2 and cancer: a new approach to an old problem [J].

Bakhle, YS .

BRITISH JOURNAL OF PHARMACOLOGY, 2001, 134 (06) :1137-1150

[10] Apoptosis induction by S-allylcysteine, a garlic constituent, during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis [J].

Balasenthil, S ;

Ra, KS ;

Nagini, S .

CELL BIOCHEMISTRY AND FUNCTION, 2002, 20 (03) :263-268

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