Liver architecture, cell function, and disease

被引：122

作者：

Ishibashi, Hiromi ^{[1
]}

Nakamura, Minoru ^{[1
]}

Komori, Atsumasa ^{[1
]}

Migita, Kiyoshi ^{[1
]}

Shimoda, Shinji ^{[2
]}

机构：

[1] Nagasaki Univ, Grad Sch Biomed Sci, Nagasaki 852, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Nagasaki, Japan

来源：

SEMINARS IN IMMUNOPATHOLOGY | 2009年 / 31卷 / 03期

关键词：

Innate immunity; Kupffer cells; Cytokine; Chemokine; Toll-like receptor; PRIMARY BILIARY-CIRRHOSIS; TOLL-LIKE RECEPTOR; PRIMARY SCLEROSING CHOLANGITIS; INTRAHEPATIC BILE-DUCTS; NF-KAPPA-B; EPITHELIAL-CELLS; T-CELLS; STELLATE CELLS; KUPFFER CELLS; IN-VIVO;

D O I：

10.1007/s00281-009-0155-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The liver is an organ consisting of the largest reticulo-endothelial cell network in the body and playing an important role in host defense against invading microorganisms. The organ is comprised of parenchymal cells and many different types of non-parenchymal cells, all of which play a significant role. Even biliary epithelial cells are not only the target in autoimmune liver diseases but also have central role in orchestrating several immune cells involved in both innate and acquired immunity. Tissue damage caused by various agents results in inflammation, necrosis, fibrosis, and, eventually, distortion of normal hepatic architecture, cirrhosis, and functional deterioration.

引用

页码：399 / 409

页数：11

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