Inhibition of VHR dual-specificity protein tyrosine phosphatase activity by flavonoids isolated from Scutellaria baicalensis:: Structure-activity relationships

被引：15

作者：

Lee, MS

Oh, WK

Kim, BY

Ahn, SC

Kang, DO

Sohn, CB

Osada, H

Ahn, JS

机构：

[1] KRIBB, Taejon 305600, South Korea

[2] Chungnam Natl Univ, Dept Food & Nutr, Taejon, South Korea

[3] RIKEN, Inst Phys & Chem Res, Wako, Saitama 35101, Japan

来源：

PLANTA MEDICA | 2002年 / 68卷 / 12期

关键词：

D O I：

10.1055/s-2002-36351

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three flavonoids: norwogonin, dihydronorwogonin and baicalein, were isolated from the roots of Scutellaria baicalensis, as potential inhibitors of VHR dual-specificity protein tyrosine phosphatase (DS-PTPase). Norwogonin (IC50 = 1.1 muM), dihydronorwogonin (IC50 = 2.9 muM) and baicalein (IC50 = 2.4 muM) showed potent inhibitory activity toward VHR, but had no inhibitory activity against T-cell protein tyrosine phosphatase or serine/threonine protein phosphatase 1. From comparisons to the inhibitory activities of other similar flavonoids, it could be suggested that the presence of a hydroxy group in the B ring of flavonoids interferes with the inhibitory activity toward VHR DS-PTPase.

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收藏

页码：1063 / 1065

页数：3

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