Maternal serum alpha-fetoprotein in fetal neural tube and abdominal wall defects at 10 to 14 weeks of gestation

被引：7

作者：

Sebire, NJ

Spencer, K

Noble, PL

Hughes, K

Nicolaides, KH

机构：

[1] UNIV LONDON KINGS COLL HOSP, SCH MED, HARRIS BIRTHRIGHT RES CTR FETAL MED, LONDON SE5 8RX, ENGLAND

[2] OLDCHURCH HOSP, DEPT CLIN BIOCHEM, ROMFORD RM7 0BE, ESSEX, ENGLAND

来源：

BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 1997年 / 104卷 / 07期

关键词：

D O I：

10.1111/j.1471-0528.1997.tb12034.x

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Maternal serum alpha-fetoprotein concentration was determined in nine pregnancies with fetal anencephaly, seven with exomphalos containing liver, two with spina bifida and 100 normal controls at 10 to 14 weeks of gestation. The median alpha-fetoprotein in the group with fetal anencephaly and exomphalos was significantly higher than in normal fetuses but the sensitivity of this test is likely to be only about 30% for a false positive rate of 5%.

引用

页码：849 / 851

页数：3

共 9 条

[1] 1ST-TRIMESTER BIOCHEMICAL SCREENING FOR FETAL CHROMOSOME-ABNORMALITIES AND NEURAL-TUBE DEFECTS [J].